Diabetes Flashcards
What is T2D associated with?(2)
Excess adiposity
Physical inactivity
What is diabetes characterised by?
Hyperglycaemia
Name the common symptoms of diabetes (5)
Thirst Excessive urination Extreme tiredness Genital itching Blurred vision
What is hyperglycaemia?
Chronically high blood glucose
What are the complications of T2D?(5)
Blindness Lower limb amputations Liver disease CVD mortality Kidney disease
Pathogenesis of T2D(4)
Insulin resistance
Central adiposity increases inflammatory cytokines being released - which affects insulin signalling
Insulin resistance increases plasma FFA
Leads to viscous cycle further increasing resistance
Pancreas beta cells unable to overcome insulin resistance
Name different methods of diagnosing T2D (3)
HbA1c (glycated haemoglobin)
OGTT
Fasting glucose
HBA1c
Reflects average plasma glucose of previous 8-12 weeks
OGTT
Patients given 75 g of glucose after overnight fast
Glucose levels measured after 2 hours
Fasting glucose
Baseline glucose levels measured after overnight fast
Risk factors of T2D (6)
Genetics Physical inactivity Age over 40 Being overweight Central adiposity IGT
Relationship between T2D and obesity (2)
Wing at al. 2011 showed that slight reduction in weight can improve glycaemic control
85% of T2D are obese
What are the diets used to treat T2D(5)
Low carb (ketogenic) Low fat Low GI/GL Mediterranean High fibre
Characteristics of low GI diet (3)
Low carb
High protein
High fat
What is fat required for?(2)
Absorption of fat soluble vitamins
Optimal hormonal production