Diabetes Flashcards
Exocrine Function of pancreas
pancreatic cells secrete directly into ducts, not bloodstream
Endocrine function of pancreas
cells secrete insulin directly into bloodstream
What is the primary source of blood sugar that our body receives?
Carbohydrates
Where are carbs broken down?
duodenum and proximal jejunum
Where does the endocrine function of the pancreas occur?
Islet of Lagernans
Alpha cells function
secrete glucagon in response to low blood sugar
Glucagon function
stimulates liver to release stored glucose into the blood
Beta cells function
produces insulin which lowers blood sugar levels by stimulating the movement of glucose into the body tissues
What hormones raise blood glucose?
Glucagon
Epinephrine
Glucocorticoids
Steroids
growth hormone
Fat sparing effect
drives cells to use carbs instead of fat for energy
What are the three results of insulin deficiency?
Decreased glucose uptake
Increased proteolysis
Increased lipolysis
Free fatty acids
alternative source of energy for tissues
excess: cholesterol and phospholipids
can lead to ketogenesis and acidosis
Short term complications of impaired fat metabolism
increased ketones
severe metabolic acidosis - coma
Long term complications of impaired fat metabolism
atherosclerosis
increased serum lipid levels
Proteolysis
body is unable to store protein efficiently
Protein catabolism
can occur in starvation pts
muscle wasting
multiple organ dysfunction
aminoacidmia
increased BUN
more typical in type 1 DM