Developmental Biology Flashcards
why is drosphilia important?
key model organism
rapid life cycle
small size
genetically tractable
what is homeosis?
changing of one body part so it resembles another
what is polarity?
regional difference in a state of commitment
what is axis?
rotation is of some pratical significance
what is potency?
total of things into which tissue can develop
why do we need model systems?
easy to manipulate quantity short gen times genomes can allow in vivo visualisation
vertebrate and invertebrate model systems?
invertebrates - drosophila, c.elegans, sea urchin, sea squirt
vertebrate - chick, zebra fish, mouse, african clawed frog
what is good about plant model organisms?
easy and inexpensive, genetic and imaging tools, mutants
arabidopsis - mustard family
what makes a suitable model organism?
rapid life cycle
small size
genetically tractable
accessible embryos
what is special about drosophila?
morphogen gradients, positional info, developmental fields, boundaries
what are morphogens?
signal molecules that can affect behaviour of a cell
what is a bicoid?
first example of a morphogen, found in drosophila
how does bicoid mRNA work?
localised to anterior pole, translated into protien spreading to posterior forming an anterior-posterior gradient
how does bcd work?
changes the levels of morphogen protein gradient shifting the position of where the target genes are activated
what happens with drosophilia segmentation?
morphogen gradient activates or represses various downstream genes depending on different thresholds for response
what does hox gene code determine?
differentiation pathways