Dermatology Flashcards
state some dermatology problems
pruritus scale alopecia crusting ulceration nodules
define pruritus
itchy skin causing self trauma
what can be causes of pruritus?
allergy
parasites
microbial infection
what can cause scale?
keratinisation disorders
what is mean by primary skin lesions?
develop in skin of own accord
define alopecia
hair loss
define bullae
localised collection of fluid over 0.5cm diameter
larger than vesicle
define erythema
diffuse or localised redness of skin which disappears with diascopy
define macule
flat circumscribed skin discolouration less than 1cm diameter without surface elevation and depression
define nodule
circumscribed solid elevation greater than 1cm usually extends into dermis
define papule
small solid elevation of the skin up to 1cm diameter
what causes papules?
infiltration of inflammatory cells, fluid, foreign material with oedema and epidermal hyperplasia
define patch
big macule, localised flat change in skin pigment larger than 1cm in diameter
define plaque
flat topped elevation of skin usually over 0.5cm, formed by coalition of papules
define pustule
small circumscribed elevation of epidermis filled with purulent material
define vesicle
small circumscribed elevation of epidermis filled with clear fluid, less than 0.5cm diameter
define wheal
sharply circumscribed raised lesion consisting of oedema, usually appears and disappears within hours
list primary skin lesions
alopecia bullae erythema macule nodule papule patch plaque vesicle wheal
list secondary skin lesions
comedone crust epidermal collarette fissure hyperkeratosis hyper and hypopigmentation lichenification scale scar ulcer
what are potential causes of secondary skin lesions?
self trauma
trauma
infections
regressing primary lesions
define comedone
dilated hair follicle filled with cornified cells and sebaceous material
define crust
dried exudate, cells, pus and scale adherent to surface
define epidermal collarette
erosion, superficial damage to epidermis
define fissure
linear cleavage into the epidermis
define hyperkeratosis
increase in thickness of cornified layer of skin
define lichenification
thickening of skin resulting in cobblestone appearance
define scale
accumulation of loose fragments of cornified layer of skin
define ulceration
full thickness loss of epidermis exposing the dermis
how do you approach diagnosing dermatological conditions?
history flea status physical exam problem list differential diagnosis of possible causes diagnostic plan for definitive cause
list diagnostic techniques for dermatology
acetate tape for cytology skin scrapings impression smear flea comb trichogram
what can be seen on acetate tape for cytology?
malassezia
bacteria
inflammatory cells squames
what can you see on skin scrapings?
demodex if deep
cheyletiella if superficial
sarcoptes
what can be seen on impression smears?
inflammatory cells
malassezia
bacteria
what can trichogram show?
anagen telogen mite and lice eggs pruritus dermatophytosis
what animals is dermatophytosis mainly found?
perisian cats but is zoonotic
what are signs of dermatophytosis?
hair loss
scaling
how is dermatophytosis diagnosed?
woods lamp to see fluorescence
microscopy to see spores
dermatophyte test medium
culture for 2 weeks at room temperature
how can dermatophytosis be treated?
products for small localised lesions
can use topical therapy
clipping to reduce load but can spread on host
systemic therapy for general or chronic infection
what is the main cause of dermatophytosis contaminating the environment?
fungal spores on hair
how can you reduce environmental contamination of dermatophytosis?
cleaning chemical agents throw away toys, bedding etc wash in antifungal disinfectant thorough vacuuming
what are indications for skin biopsies?
neoplasia generalised dermatosis conditions poorly responsive to therapy no results from other tests vesicles bullae erosions ulcers
describe how skin biopsies are done
LA, sedation or GA
clip hair but dont prepare skin as removes pathogens
take from multiple sites and fully developed lesions
avoid traumatised lesions
punch 4-8mm wide and excise
where do skin biopsies get sent?
histopathology
culture
cytology
what can be results from submitting skin biopsies?
diagnosis
compatible with clinical diagnosis
not compatible with clinical diagnosis
non-diagnostic
what is meant by the itch scratch cycle?
once itchy continues to scratch
itching influenced by flare factors
list flare factors
fleas bacteria yeast dry skin sweating psychological factors
how is pruritus clinically assessed?
visual analogue scale from normal to itching taking over normal tasks
itching behaviours
how do animals develop clinical signs of allergic dermatitis?
increase in allergic load pushes over amount they can tolerate
what are clinical signs of canine atopic dermatitis?
alopecia erythema excoriation hyperpigmentation lichenification self trauma secondary infections
how is canine atopic dermatitis diagnosed?
rule out other pruritic causing conditions
intradermal and blood testing to select allergens for immunotherapy
what is the purpose of canine atopic dermatitis allergy testing?
doesnt diagnose
identify allergens of clinical significance
basis for allergen specific immunotherapy and desensitisation
what are examples of microbial infection?
pyoderma
malassezia
what are clinical signs of pyoderma?
intraepidermal pustules easily disrupted
transient primary lesions
secondary crusting, erosion lesions
peripheral spread with peeling epidermal collarette
recurring disease if underlying cause unmanaged
what are common underlying disorders of pyoderma?
ectoparasites
allergy
endocrinopathies
what are the two types of pyoderma?
superficial
deep
what is the main cause and signs of deep pyoderma?
demodex
weepy skin, infection in skin follicle
list antibiotics used for pyoderma treatment
clindamycin
trimethoprim
clavulanic acid and amoxicillin
cefalexin
how long does it normally take to treat superficial pyoderma?
3-4 weeks
how can topical treatments help treat pyoderma?
remove scale, crust and exudate
reduce bacterial number
promote drainage of deeper lesions
reduce pain and pruritus
what is malassezia pachydermatitis?
opportunistic yeast pathogen
where does malassezia normally live?
external ear canal
chin
perioral
interdigital
what is the effect of malassezia infection?
hypersensitivity to microbes agents
what predisposes to malassezia infection?
alteration in skin microclimate, sebum, moisture
allergic and bacterial skin disease
what are clinical signs of malassezia infection?
pruritus effects ventral region, feet, face, skin folds erythema scale hyperpigmentation malodour
how is malassezia infection diagnosed?
impression smears
acetate strip preparations
culture
how can you treat malassezia?
topical chlorhexidine therapy 2x weekly
systemic itraconazole therapy for 7 days
what is main sign of malassezia otitis?
otitis externa
what is the cause of malassezia otitis?
ceruminous glands provide lipid rich material for bacteria to survive
how can you treat malassezia otitis?
steroids to control cerumen production
describe the lifecycle of fleas
intermediate stages found in environment
fleas stay on host unless removed by scratching etc
what is flea bite hypersensitivity?
clinical condition in animals sensitised to antigenic components of flea saliva
how is flea bite hypersensitivity diagnosed?
history compatible clinical signs flea evidence dipylidium caninum infestation positive response to flea treatment elimination of differential diagnoses serology testing for flea saliva antigen
what can affect the efficacy of flea control?
formulation application hair length bathing insect growth development inhibitors in environment
what are control measures for fleas in environment?
thorough vacuuming to remove eggs, debris and faeces
what is the main aim of flea control and how is it achieved?
prevention using prophylaxis
how are animals with flea allergy dermatitis treated?
insecticides long term insect growth inhibitor glucocorticoids antibiotics if needed preventative control
what prevents management of fleas?
not treating all animals contacted
not preventing
not removing all fleas from environment
what are signs of demodex?
itchy skin
alopecia
crusting
secondary infection
what can be seen on histology caused by demodex?
folliculitis
furunculosis
nodular dermatitis
how is demodex diagnosed?
deep skin scraping
hair plucks
skin biopsy
observation of lesions general or local
what is prognosis for generalised demodicosis?
50% spontaneously recover as immune system matures
good with treatment
when does localised demodicosis affect animals?
juveniles
what is the effect of localised demodicosis?
mild disease rarely becoming generalised
focal alopecia and erythema
where does local demodicosis normally affect?
legs and head
why is localised demodicosis normally not treated?
spontaneously resolve
what animals are prone to adult onset demodex?
immunocompromised corticosteroids hyperadrenocorticism neoplasia hypothyroidism
how is demodex treated?
acaridicidal treatment
manage bacterial pyoderma with oral cefalexin and chlorhexidine baths
describe the lifecycle of sarcoptes scabei?
3 weeks long
eggs laid in deep burrows in host
what are signs of sarcoptes scabei infection?
pruritus
hypersensitivity
how is sarcoptes scabei diagnosed?
skin scrapings
skin biopsies, rarely diagnostic
ELISA blood test
transmission between contacts or environment
how is sarcoptes scabei treated?
treat concurrent staphylococcal infections
corticosteroids for pruritus
treat mites
state an example of ear mites
otodectes cynotis
what are signs of ear mites?
irritation
hypersensitivity
how are ear mites treated?
give to all animals in house
remove wax before applying topical treatment
what is cheyletiellosis?
large surface mites
obligate parasites
zoonotic and highly contagious
where does cheyletiellosis live?
epidermal pseudo-tunnels feeding on tissue fluids
eggs attached to hair
what are signs of cheyletiellosis?
hypersensitivity lesions scaling mild pruritus dermatitis alopecia
how is cheyletiellosis diagnosed?
microscopy to identify mites or eggs
hair plucks
superficial skin scrapings
acetate tape impressions
how us cheyletiellosis treated?
selamectin monthly
moxidectin
baths or sprays
what are harvest mites?
6 legged larvae of trombicula autumnalis
describe the life cycle of harvest mites
most prevalent in autumn as orange larvae on vegetation
attach to host and feed for 3 days
complete lifecycle in environment
what are signs of harvest mite infection?
erythema
papules
crusting
hypersensitivity
where do harvest mites tend to live on animals?
pinnae
pre-auricular regions
interdigital spaces
eyelids
how is harvest mite infestation diagnosed?
observing 6 legged orange larvae confirmed by microscopy
how are harvest mites treated?
flea products
glucocorticoids for hypersensitivity
fipronil spray to prevent attachment
describe typical lice lifecycle
2-3 weeks
eggs attach to hairs
hatch
3 nymph stages before adult
what are clinical signs of lice?
pruritus
scaling of dorsum
self trauma
how are lice infestations diagnosed?
exam for eggs or adults
acetate tape impression
coat brushings
hair pluckings
how are lice treated?
selamectin
moxidectin
clip heavily infested animals to reduce burden and allow topical therapy to be effective
what is the problem of ticks?
carry tick borne diseases such as encephalitis, lyme
how are ticks prevented?
monthly tick control
what are the hosts for echinococcus granulosus?
DH- carnivores
IH- humans, sheep that ingest DH
what is the effect of echinococcus granulosus infection on IH?
humans- cysts in liver and lungs
sheep- production losses
how is echinococcus granulosus infection diagnosed in IH?
post mortem
ultrasound
radiography
how is echinococcus granulosus treated?
DH- praziquantel
IH- no treatment
how can echinococcus granulosus be controlled?
dog treatment and control
meat inspection before consumption
disposal of offal
what stage of taenia causes issues?
intermediate stage
how can you control taenia infection?
prevent dogs eating offal
stop sheep eating eggs in dogs defecations
up to date worming
what are the hosts for taenia?
DH- dog
IH- sheep
what is the effect of taenia infection in sheep?
space occupying lesions
destruction of coenurus cerebralis
head tilt
what are the hosts for echinococcus multiocularis?
DH- dog, fox, cat
IH- rodents, humans
spend some time not on host
what is the lifecycle of toxocara canis?
hepato tracheal migration
somatic arrest in various body tissue in adults
reactivation by transplacental and transmammary infection
how is toxocara canis treated and controlled?
routine worming
early worming puppies
what are worming products used for toxocara canis prevention?
benzimidazoles
endectocides
piperazine citrate
praziquanal
what is normal puppy worming protocol for toxacara canis?
week 2, 4, 6, 9, 12
every 3 months
what is the protocol for worming pregnant bitches?
fenbendazole daily from day 42 to 2 weeks post whelping
only reduces not removes so assume all pups infected
what is routine worming protocol in dogs?
monthly to 3 monthly
test and treat
remove faeces
how are kittens treated for worms and why?
from 3-4 weeks as only transmammary not transplacental transmission
why do you need to worm cats?
hunt and eat hosts containing worm
what are signs of early angiostrongylus infection?
coughing dyspnoea anaemia depression anorexia coagulopathy
what are signs of chronic angiostrongylus infection?
verminous pneumonia
anorexia
emaciation
pulmonary hypertension
how is angiostrongylus diagnosed?
faecal exam
blood test
define macroscopic
visible with naked eye but need microscope to distinguish
how do lice eggs attach to host?
attach to hairs with cement
how is identity of surface mites confirmed?
magnification
state type of fur mites
cheyletiella spp
state type of ear mites
otodectes
where do ear mites reside?
superficially feeding on ear debris
eggs in ear canal
define microscopic
need microscope to see and identify