Dermatologic Pharmacology Flashcards
Percutaneous absorption is what kind of absorption process
diffusion process
What layer of the epidermis is the rate limiting step for percutaneous absorption
stratum corneum
In Fick’s law what directly increases M drug amount in receptor phase
D - diffusion constant
C - concentration of donor drug
In Fick’s law what has an inverse relationship with M - drug amount in receptor phase
h - skin thickness
Diffusion laws: what increases J - amount of drug penetrating
Km- solubility
Dm - diffusion coefficient
Diffusion laws: what decreases J - amount of drug penetrating
Th - thickness of skin
diseased or non-intact skin has what effects
increase percutaneous absorption
decrease transepidermal water loss
in what time in you life do you have the greatest skin permeability
preterm infant
aged skin more permeable
shunt diffusion
transient and small amount of substances diffuse through hair follicles and eccrine glands
where is the highest rate of drug penetration
- scrotum, post-auricular, eyelid, scalp, soles, palms
- body folds
- diffusion shunts
what does temperature effect absorption
increase temperature increase diffusion
how does increasing hydration of s. corneum effect percutaneous absorption? This concept can treat what?
increases
- inflammatory skin disease
what does hydration do the blood vessels
vasoconstriction
which one has greater absorption
- high concentration of 1 dose
- equally divided doses of lesser concentration
1.
tachyphylasxis
rapidly diminishing response to successive doses of a drug, rendering it less effective.
