Bones 2 Flashcards

1
Q

osteoma defect where on bone

A

subperiosteal or endosteal cortex surface

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2
Q

what type of bone is impacted with osteoma

A

woven and lamellar bone

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3
Q

what is gardner syndrome

A

multiple osteomas

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4
Q

compare sizes of osteoid and osteoblastoma

A

osteoid: less than 2 cm
osteoblastoma: greater than 2 cm

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5
Q

can NSAIDS be used for relief of osteoid and osteoblastoma

A

osteoid: yes
osteoblastoma: no ``

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6
Q

most common nonhematopoetic malignant primary bone tumor

A

osteosarcoma

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7
Q

what is made in osteosarcoma?

A

osteoid

-painful enlarging mass

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8
Q

what age groups are impacted by osteosarcoma

A

75% less than 20

elderly

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9
Q

osteosarcoma is associated with what disease

A

paget’s disease

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10
Q

what is Codman triangle

A

osteosarcoma tumor lifts periostium

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11
Q

where does osteosarcoma usally occur on bone

A

metaphysis medulla, knee

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12
Q

osteosarcoma: hereditary retinoblastoma is a defect in what gene

A

RB

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13
Q

osteosarcoma: Li-Fraumeni syndrome defect in

A

p53

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14
Q

osteosarcoma metastazies where

A

lung

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15
Q

Osteochondroma exostosis what happens

A

mushroom-shaped cartilage-capped

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16
Q

where does Osteochondroma exostosis occur

A

metaphysis: near growth plate of long tubular bones, especially around knee

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17
Q

Osteochondroma exostosis: multple heredity exotosis isa defect in what gene and how is passed on

A

EXT1 and EXT2

autosomal dominant

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18
Q

how fast does osteochondrom grow? pain? increases risk for what

A

slow growing, stops with closure of growth plate

- Multiple Hereditary exostosis

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19
Q

Chondroma is what

A

benign hyaline cartilage tumor

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20
Q

where is enchondroma

A

phalynx

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21
Q

where does subperiotsteal chondroma occur

A

surface of bone

22
Q

what does enchondroma look like

A

less than 3cm grey-blue

nodules of hyaline cartilage with peripheral enchondral ossification

23
Q

enchondroma is a risk of turning into

A

Enchondromatosis ( Ollier disease)

Maffucci syndrome: enchondromas with hemangiomas

24
Q

most common place for enchondroma tumor

A

phalynx

25
Q

chondroblastoma is seen in what age group

A

teenagers

26
Q

chondroblastoma most common place found where on body

A

KNEE EPIPHYSIS

27
Q

define chondrosarcoma

A

no malignant bone formation

28
Q

where does chondrosarcoma occur

A

intramedullary

juxtacortical and surface

29
Q

histo of chondrosarcoma

A

clear cell
differentiated
mesynchymal

30
Q

what are the 3 patterns for fibrous dyspasia

A

monostotic

  • polystotic with soft tissue myxomas
  • polyostotic with endocrine dysfunction
31
Q

what does the X-ray look like for fibrous dysplasia

A

ground glass and well-demarcated

32
Q

where on bone does fibrous dysplasia occur

A

diaphysis

33
Q

fibrous dysplasia: monostatic where does it usually occur? who does it occur in

A

ribs femur tibia

teens

34
Q

fibrous dysplasia: polyostatic, is what two diseases

A

Mazabraud syndrome

McCune-Albright syndrome

35
Q

fibrous dysplasia: McCune-Albright syndrome? clinical presentaiotn
endocrine?

A

cafe au lait skin pigmentations

sexual precocity, hyperthyroidism

36
Q

fibrous dysplasia histo

A

chinese character woven bone in fibrous stroma

37
Q

what is Ewing Sarcoma family

A

small round blue cell tumor of bone and soft tissue

38
Q

gene translocation for ewing sarcoma

A

T(11;22)

EWS-FLI1

39
Q

Ewing occurs where in bone

A

medullary cavitity but invades cortex into soft tissue

- dipahysis of long bone

40
Q

other symptoms with Ewing

A

fever, anemia, leukocytosis

41
Q

what is giant cell tumor of bone

A

benign locally aggressive tumor of macrophage/monocyte system

42
Q

mononuclear cells have what receptor

A

RANKL

43
Q

where on bone does giant cell tumor occur

A

epiphysis may extend to metaphysis

44
Q

most common location of ewing

A

knee

45
Q

Aneurysmal bone cyst (ABC)

A

multiloculated blood-filled cysts

46
Q

where does Aneurysmal bone cyst (ABC) occur

A

metaphysis of long bones and vertebrae

47
Q

most common form of skeletal malignancy

A

metastatic disease

48
Q

how can metastatic disease spread to bone

A

direct
lymph or hematogenous
-intraspinal ( batson plexus of veins)

49
Q

bone tumors of metaphysis

A
osteoid osteoma
osteochondroma
osteosarcoma
chondroma
fibrous dysplasia
fibrous cortical defect 
ABC
50
Q

bone tumor on epiphysis

A

clear cell chondrosarcoma

chondroblastoma

51
Q

bone tumor on diaphysis

A

ewing sarcoma

firbous dysplaisa

52
Q

bone tumor on epiphysis/metaphysis

A

giant cell tumor aneurysmal bone cyst