derm - conditions Flashcards
causative agent for impetigo?
GAS
S. Aureus
treatment for impetigo?
remove crusts
topical antibacterials: mupirocin/fusidic acid
systemic antis, cloxacillin or cephalexin
topical antifungalsfirst line for tinea?
clotrimazole
terbinafine
ciclopirox olamine
when antifungal oral therapy?
oncomycosis
tinea capitis
what is pemphigus vulgaris etiology?
autoimmune
igG produced against epidermal desmoglein 1 and 3
what is pemphigus vulgaris Nikolsky’s sign?
shear stress epidermal detachment
where does pemphigus vulgaris 90% happen?
mouth then scalp, face, chest etc.
pemphigus vulgaris treatment?
pred: 1mg/kg
then
immunosuppressant: aza, cyclo, mycophenolate, ritux, IVIG
Stevens-Johnson syndrome/Toxic epidermal necrolysis affects?
skin/mucous membranes
Stevens-Johnson syndrome/Toxic epidermal necrolysis time course
1-3 weeks after drug initiation
Stevens-Johnson syndrome/Toxic epidermal necrolysis type of immune response
type IV hypersensitivity
T-cell-mediated attacks epithelial and muscosa
Stevens-Johnson syndrome % of body surface?
<10%
10-30%
Toxic epidermal necrolysis % TBsA?
> 30%
Stevens-Johnson syndrome/Toxic epidermal necrolysis triggers common:
carbamazapine
sulfa
immunomodulators
NSAIDS: piroxicam
2 infections that can cause Stevens-Johnson syndrome/Toxic epidermal necrolysis?
mycoplasma pneumoniae
CMV