Deck 7

Question 1

Supermethrin causes

Answer 1

Cyanhaemoglobin (HbCN) - cyanide released during biotransformation

Question 2

Therapy of cyanide poisoning

Answer 2

SODIUM NITRITE –> MtHb is formed, cyanide binds to it creating cyanmethemoglobin (MtHbCN), & then after application of sodium thiosulphate (Na2S2O3), the non-toxic SCN- is formed & eliminated in urine

Question 3

Clinical significance of enzyme determination

Answer 3

• Diagnosis of sub-clinical disease
• Diagnosis of disease when manifesting
  phase has only the common symptoms
• Determination of degree of organ damage
• Determination of prognosis & efficiency of
  therapy according to time dependent dynamics of enzyme level

Question 4

Examples of cell-indicator enzymes

Answer 4

• AST (aspartate aminotransferase)
• ALT (alanine aminotransferase)
• LDH (lactodehydrogenase)
• Acetylcholinesterase
• Alkaline & acidic phosphatase

Question 5

Benzidine test used for

Answer 5

Qualitative determination of cyanide (blue colour)

Question 6

LD50 of MCPA in animals

Answer 6

50-500 mg/kg BW

Question 7

LD50 of monensin

Answer 7

22-50 mg/kg BW (2-3mg/kg in horses!)

Question 8

Carbamate aldicarb (extremely toxic) clinical signs in humans

Answer 8

o Nausea
o Hypersalivation
o Sweating
o Vom, D+
o Abdom pain
o Visual disturbances & miosis o Dyspnoea
o Muscular tremor

Question 9

Carbamate aldicarb (extremely toxic) clinical signs in animals

Answer 9

o Spasms
o Hyperexcitability
o Opistotonus
o Lethargy
o Miosis or mydriasis, blindness
o Ataxia, muscular weakness
o Tachypnoea, dyspnoea
o Emesis, D+
o Piloerection
o Lacrimation
o Ptosis
o Death due to resp arrest & hypoxia

Question 10

Atropine is

Answer 10

An alkaloid that depresses the heart & CNS