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FlashCards for Quizes PRELIMS > DDS QUIZ LEC Powders and Granules > Flashcards

DDS QUIZ LEC Powders and Granules Flashcards

1
Q

What is the purpose of particle size analysis?

A

obtain quantitative data on the size distribution and shapes of the drug and other components to be used in pharm. formulations

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2
Q

Particle size that can influence a variety of important factors

A

1 Dissolution rate
2 Suspendability
3 Uniform distribution
4 Penetrability
5 Lack of grittiness

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3
Q

What are the Methods of Comminution of Drugs

A

1 Trituration or comminution
2 Mills/ pulverizers
3 Levigation

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4
Q

Grinding a drug in a mortar to reduce particle size; may be both employed to comminute and to mix powders

A

Comminution or Trituration

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5
Q

Rapidly moving blades in the comminuting chamber and passed through screen of desired dimension

A

Mills/ pulverizers

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6
Q

It is commonly used in small-scale preparation of ointments and suspensions to reduce the particle size and grittiness of added powders.

A

Levigation

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7
Q

What are the examples of levigating agents

A

mineral oil and glycerin

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8
Q

Blending small amounts of powders by movement of a spatula through a sheet of paper or an ointment tile

A

Spatulation

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9
Q

Is spatulation suitable for large quantities of powders?

True or False?

A

False
(it is not suitable for large quantities of powders)

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10
Q

It is a mixture of two or more components that produces a change of phase to liquid at a certain temperature?

A

Eutectic mixture

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11
Q

It is the temperature at which such systems exists in the liquid phase.

A

Eutectic Temperature

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12
Q

Above this temperature, the components are liquids and below this temperature are solids?

A

Eutectic Temperature

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13
Q

What are the examples of Eutectic temperature?

A

Phenol
camphor
menthol
thymol
and other similar chemicals

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14
Q

It is used when a small amount of potent substance is to be mixed with large amount of diluent to ensure uniform distribution of the potent drug?

A

Geometric Dilution

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15
Q
A
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16
Q

Large scale manufacturing

A

Sifting
Tumbling

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17
Q

what are special considerations when blending?

A

1 Eutectics
2 Powder adsorbent
3 Hygroscopic and Deliquescent powders
4 Efflorescent powders

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18
Q

How to keep powders dry?

A

add magnesium oxide or magnesium carbonate

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19
Q

It contains water of hydration or crystallization?

A

Efflorescent Powders

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20
Q

Powders may become sticky or pasty or they may liquefy when mixed together

A

Eutectics

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21
Q

Medicated Powders - classification of powders

A

Aerosol powders
Bulk Powders
Divided Powders
Insufflations
Effervescent Powders
Dusting Powders
Dentrifices
Douche Powders

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22
Q

Administered by inhalation? (e.g. MDI)

A

Aerosol Powders

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23
Q

Limited to non-potent substances (e.g. antacids and laxatives)

A

Bulk Powders

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24
Q

Packed in a small piece of paper (e.g. analgesic powders)

A

Divided powders

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25
A thin semi opaque paper with limited moisture resistance?
Vegetable parchment
26
Glazed,transparent paper, also with limited moisture resistance
Glassline
27
Transparent, water-proof paper
Waxed Paper
28
Just press (info on the types of papers)
The selection of the type of paper is based on the primary nature of the powder
29
These powders are usually applied with and applicator knowns as?______ ; introduced into different body cavities such as nose, ear, vagina, tooth sockets etc.
Insufflations
30
These powders when mixed with water show effervescence with the liberation of carbon dioxide (e.g. citric acid, tartaric acid)
Effervescent Powders
31
Are used externally for local application, not intended for systematic action (e.g. talc, kaolin, starch, zinc oxide)
Dusting Powders
32
Are bulk powders for external use to clean teeth; mainly contain an abrasive agent.
Dentrifices
33
It contains a surfactant, mild soap/detergents and sweetening agents?
Dentrifices
34
Commonly used for vaginal use and intended for the action of cleansing agents or used as an antiseptic
Douche Powders
35
What are the advantages of Powders?
Can be administered easily to infants/ young children who cannot swallow tablets/ capsules It has a rapid onset of action since disentegration is not required Can be made into different dosage formulas
36
What are the disadvantages of Powders?
Bitter unpleasant taste Inaccuracy of dose Individually wrapped doses of powders may increase manufacturing expense Patient may misunderstand method of use difficult to protect powders containing hygroscopic deliquescent ( tending to melt or dissolve in humid environment), or aromatic material from decomposition
37
They are usually in the 4-12 mesh sieve size range?
Granules
38
They are prepared by wet method and dry method?
Granules
39
Methods of preparation in Granules?
Wet Method Fluid Bed Processing Dry Method
40
41
42
43
Fine particles
Powder
44
Can be applied to the body?
Powder
45
smooth to touch
Powder
46
Poor flow properties?
Powder
47
Physically and chemically less stable?
Powder
48
Produce more dust?
Powder
49
It is a small grain?
Granules
50
Cannot be applied to the body?
Granules
51
they are rough?
Granules
52
they flow well
Granules
53
Physically and chemically more stable?
Granules
54
Produce less dust?
Granules
55
What are the method of preparation in effervescent salts?
Dry or Fusion Method Wet Method
56
They are granules or coarse to very coarse powders containing a medicinal agent in a dry mixture and is usually composed of sodium bicarbonate, citric acid, and tartaric acid?
Effervescent Salts
57
When added to water, the acids and the base react tot liberate carbon dioxide, resulting in?
Effervescence
58
Using a combination of citric and tartaric acid rather than either acid alone avoids certain difficulties
Effervescence
59
What would happen to tartaric acid when used alone?
lose their firmness and crumbles
60
What would happen to Citric acid when used alone?
Sticky mixture and difficult to granulate
61
Pang gamit ug sulod sa mga powders
Chartula/Chartulae
62
They are intimate mixtures of dry, finely divided drugs and/ or chemicals that may be intended for internal or external use (USP)
Powders
63
A dosage form composed of a solid or mixture of solids to finely divided state and intended for internal or external use (Ansel)
Powders
64
They can be an intermediary for drugs normally administered as a solution or suspension in an aqueous vehicle.
Powders
65
These are reconstituted just prior to use to avoid chemical degradation (e.g. antibiotic powders for syrups and powders for injection)
Powders
66
Used for inhalation (pulmonary or nasal) and for external use
Powders
67
It may be incorporated into semisolid bases: ointment and creams
Powders
68
what are the methods for determination of size particles?
Sieving Microscopy Sedimentation Rate Light energy diffraction Laser holography Cascade Impaction
69
What no. is very coarse?
No.8
70
What no. is Coarse?
No. 20
71
What no. is moderately coarse?
No. 40
72
What no is fine?
No. 60
73
What no. is very fine?
No. 80
74
and not more that 20% pass through a No. 60 sieve?
Very coarse (No. 8)
75
not more that 40% pass through a No. 60 sieve?
Coarse (No. 20)
76
Not more that 40% pass through a No. 80 sieve?
Moderately Coarse (No. 40)
77
not more than 40% pass through a No. 100 sieve?
Fine (No. 60)
78
There is no limit greater fineness
Very Fine (No. 80)
79
UPS uses these descriptive terms to characterize particle size?
Very Coarse Coarse Moderately Coarse Fine Very Fine

FlashCards for Quizes PRELIMS (14 decks)

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