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FlashCards for Quizes PRELIMS > DDS QUIZ LEC Powders and Granules > Flashcards

DDS QUIZ LEC Powders and Granules Flashcards

1
Q

What is the purpose of particle size analysis?

A

obtain quantitative data on the size distribution and shapes of the drug and other components to be used in pharm. formulations

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2
Q

Particle size that can influence a variety of important factors

A

1 Dissolution rate
2 Suspendability
3 Uniform distribution
4 Penetrability
5 Lack of grittiness

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3
Q

What are the Methods of Comminution of Drugs

A

1 Trituration or comminution
2 Mills/ pulverizers
3 Levigation

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4
Q

Grinding a drug in a mortar to reduce particle size; may be both employed to comminute and to mix powders

A

Comminution or Trituration

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5
Q

Rapidly moving blades in the comminuting chamber and passed through screen of desired dimension

A

Mills/ pulverizers

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6
Q

It is commonly used in small-scale preparation of ointments and suspensions to reduce the particle size and grittiness of added powders.

A

Levigation

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7
Q

What are the examples of levigating agents

A

mineral oil and glycerin

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8
Q

Blending small amounts of powders by movement of a spatula through a sheet of paper or an ointment tile

A

Spatulation

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9
Q

Is spatulation suitable for large quantities of powders?

True or False?

A

False
(it is not suitable for large quantities of powders)

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10
Q

It is a mixture of two or more components that produces a change of phase to liquid at a certain temperature?

A

Eutectic mixture

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11
Q

It is the temperature at which such systems exists in the liquid phase.

A

Eutectic Temperature

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12
Q

Above this temperature, the components are liquids and below this temperature are solids?

A

Eutectic Temperature

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13
Q

What are the examples of Eutectic temperature?

A

Phenol
camphor
menthol
thymol
and other similar chemicals

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14
Q

It is used when a small amount of potent substance is to be mixed with large amount of diluent to ensure uniform distribution of the potent drug?

A

Geometric Dilution

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15
Q
A
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16
Q

Large scale manufacturing

A

Sifting
Tumbling

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17
Q

what are special considerations when blending?

A

1 Eutectics
2 Powder adsorbent
3 Hygroscopic and Deliquescent powders
4 Efflorescent powders

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18
Q

How to keep powders dry?

A

add magnesium oxide or magnesium carbonate

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19
Q

It contains water of hydration or crystallization?

A

Efflorescent Powders

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20
Q

Powders may become sticky or pasty or they may liquefy when mixed together

A

Eutectics

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21
Q

Medicated Powders - classification of powders

A

Aerosol powders
Bulk Powders
Divided Powders
Insufflations
Effervescent Powders
Dusting Powders
Dentrifices
Douche Powders

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22
Q

Administered by inhalation? (e.g. MDI)

A

Aerosol Powders

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23
Q

Limited to non-potent substances (e.g. antacids and laxatives)

A

Bulk Powders

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24
Q

Packed in a small piece of paper (e.g. analgesic powders)

A

Divided powders

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25
Q

A thin semi opaque paper with limited moisture resistance?

A

Vegetable parchment

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26
Q

Glazed,transparent paper, also with limited moisture resistance

A

Glassline

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27
Q

Transparent, water-proof paper

A

Waxed Paper

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28
Q

Just press (info on the types of papers)

A

The selection of the type of paper is based on the primary nature of the powder

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29
Q

These powders are usually applied with and applicator knowns as?______ ; introduced into different body cavities such as nose, ear, vagina, tooth sockets etc.

A

Insufflations

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30
Q

These powders when mixed with water show effervescence with the liberation of carbon dioxide (e.g. citric acid, tartaric acid)

A

Effervescent Powders

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31
Q

Are used externally for local application, not intended for systematic action (e.g. talc, kaolin, starch, zinc oxide)

A

Dusting Powders

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32
Q

Are bulk powders for external use to clean teeth; mainly contain an abrasive agent.

A

Dentrifices

33
Q

It contains a surfactant, mild soap/detergents and sweetening agents?

A

Dentrifices

34
Q

Commonly used for vaginal use and intended for the action of cleansing agents or used as an antiseptic

A

Douche Powders

35
Q

What are the advantages of Powders?

A

Can be administered easily to infants/ young children who cannot swallow tablets/ capsules

It has a rapid onset of action since disentegration is not required

Can be made into different dosage formulas

36
Q

What are the disadvantages of Powders?

A

Bitter unpleasant taste

Inaccuracy of dose

Individually wrapped doses of powders may increase manufacturing expense

Patient may misunderstand method of use

difficult to protect powders containing hygroscopic deliquescent ( tending to melt or dissolve in humid environment), or aromatic material from decomposition

37
Q

They are usually in the 4-12 mesh sieve size range?

A

Granules

38
Q

They are prepared by wet method and dry method?

A

Granules

39
Q

Methods of preparation in Granules?

A

Wet Method
Fluid Bed Processing
Dry Method

40
Q
A
41
Q
A
42
Q
A
43
Q

Fine particles

A

Powder

44
Q

Can be applied to the body?

A

Powder

45
Q

smooth to touch

A

Powder

46
Q

Poor flow properties?

A

Powder

47
Q

Physically and chemically less stable?

A

Powder

48
Q

Produce more dust?

A

Powder

49
Q

It is a small grain?

A

Granules

50
Q

Cannot be applied to the body?

A

Granules

51
Q

they are rough?

A

Granules

52
Q

they flow well

A

Granules

53
Q

Physically and chemically more stable?

A

Granules

54
Q

Produce less dust?

A

Granules

55
Q

What are the method of preparation in effervescent salts?

A

Dry or Fusion Method
Wet Method

56
Q

They are granules or coarse to very coarse powders containing a medicinal agent in a dry mixture and is usually composed of sodium bicarbonate, citric acid, and tartaric acid?

A

Effervescent Salts

57
Q

When added to water, the acids and the base react tot liberate carbon dioxide, resulting in?

A

Effervescence

58
Q

Using a combination of citric and tartaric acid rather than either acid alone avoids certain difficulties

A

Effervescence

59
Q

What would happen to tartaric acid when used alone?

A

lose their firmness and crumbles

60
Q

What would happen to Citric acid when used alone?

A

Sticky mixture and difficult to granulate

61
Q

Pang gamit ug sulod sa mga powders

A

Chartula/Chartulae

62
Q

They are intimate mixtures of dry, finely divided drugs and/ or chemicals that may be intended for internal or external use (USP)

A

Powders

63
Q

A dosage form composed of a solid or mixture of solids to finely divided state and intended for internal or external use (Ansel)

A

Powders

64
Q

They can be an intermediary for drugs normally administered as a solution or suspension in an aqueous vehicle.

A

Powders

65
Q

These are reconstituted just prior to use to avoid chemical degradation (e.g. antibiotic powders for syrups and powders for injection)

A

Powders

66
Q

Used for inhalation (pulmonary or nasal) and for external use

A

Powders

67
Q

It may be incorporated into semisolid bases: ointment and creams

A

Powders

68
Q

what are the methods for determination of size particles?

A

Sieving
Microscopy
Sedimentation Rate
Light energy diffraction
Laser holography
Cascade Impaction

69
Q

What no. is very coarse?

A

No.8

70
Q

What no. is Coarse?

A

No. 20

71
Q

What no. is moderately coarse?

A

No. 40

72
Q

What no is fine?

A

No. 60

73
Q

What no. is very fine?

A

No. 80

74
Q

and not more that 20% pass through a No. 60 sieve?

A

Very coarse (No. 8)

75
Q

not more that 40% pass through a No. 60 sieve?

A

Coarse (No. 20)

76
Q

Not more that 40% pass through a No. 80 sieve?

A

Moderately Coarse (No. 40)

77
Q

not more than 40% pass through a No. 100 sieve?

A

Fine (No. 60)

78
Q

There is no limit greater fineness

A

Very Fine (No. 80)

79
Q

UPS uses these descriptive terms to characterize particle size?

A

Very Coarse
Coarse
Moderately Coarse
Fine
Very Fine

FlashCards for Quizes PRELIMS (14 decks)

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