CVR 18 lipoproteins

Question 1

What are lipoproteins

Answer 1

spherical transport lipids to and from tissues

Question 2

What are the types of lipos

Answer 2

chylomicrons
HDL
LDL
VLDL

Question 3

Order of density greatest to least

Answer 3

chylo, VLDL, LDL, HDL

Question 4

What are apoplipoproteins

Answer 4

vital for structure
ligands for cell surface
co enzymes for lipid metabolism

Question 5

What are the 5 major classes of apopliproteins

Answer 5

ABCDE

Question 6

How are fats transported in circulation

Answer 6

chylomicrons

Question 7

Where are apoliprotein made

Answer 7

ER by B48

Question 8

Where is lipid made

Answer 8

Smooth ER

Question 9

where are chylomicrons assembled

Answer 9

B48 loaded with lipid and moved to golgi apparatus and packaged

Question 10

How are chylomicrons matured

Answer 10

in plasma by echange with HDL

Question 11

What enzyme is needed for utilizying chylomicron by tissue

Answer 11

lipoprotein lipase LPL

Question 12

How is chylomicron cleared

Answer 12

As Tg’s are removed they get smaller and denser and lose Apo C which liver than removes

Question 13

How is LDL delivered to tissues

Answer 13

receptor mediated endocytosis via Apo B100 NOT B48

Sees Apo E

Question 14

What is SR-A

Answer 14

scavener receptor class A in macrophages which takes up LDL when Apo B is oxidised turning them into foam cells which is key to formong atherscleotic plaque

Question 15

What is involved in forming HDL

Answer 15

Apo A C E

Question 16

What does HDL do

Answer 16

Reservoir of apo C and E
accumulating cholestorol
esterification
REVERSE CHOLESTEROL TRANSPORT back to liver and converting to bile

Question 17

Disorder of VLDL and chylomicrone

Answer 17

hypertriglceridaemia

Question 18

disorder of LDL

Answer 18

hypercholesterolaemia

Question 19

Disorder of HDL

Answer 19

tangier disease