CV micro Diebel

Question 1

Non-tender, small hemorrhagic lesions on palms and soles?

Answer 1

Janeway lesions

Vascular phenomena–histology consistent with septic micro-emboli

type II hypersensitivity????

Question 2

Red-purple, tender, papular, lesions usually on pads of fingers and toes?

Answer 2

Osler’s nodes

Immunological phenomena

type III hypersensitivity

Question 3

Two pieces of Duke Criteria other than Osler’s nodes and Janeway lesions:

Answer 3

Rheumatoid factor

Roth’s spots (retinal hemorrhage????)

Question 4

VF’s for Strep viridans?

Disease association?

Answer 4

dextran–> glycocalyx formation

FimA, GspB — surface adhesion proteins

subacute/chronic infectious endocarditis

Question 5

VF for Strep pneumo?

Answer 5

capsule— evades Ab response

Question 6

VF for Strep pyogenes?

Answer 6

capsule — evades Ab response

Streptokinase (converts plasminogen to plasmin)

 M protein (resists phagocytosis)

 Hyaluronidase (breaks down connective tissue)

 DNase (digests DNA)

 Streptolysin O (destroys RBCs)

 Streptolysin S (destroys WBCs)

 Streptokinase and hyaluronidase are encoded by a lysogenized prophage

Question 7

S. aureus VF’s:

Answer 7

Capsule

biofilm formation

elastin, collagen, fibronectin

coagulase

leukocidin

Question 8

VF for coxackie/adeno viruses:

Answer 8

CAR binding proteins

Question 9

R. rickettsia VF’s:

Answer 9

OmpA, OmpB — attachment

Type 4 secretion system — host cell entry

Question 10

Dx test for RMSF?

Answer 10

tissue biospy–> PCR for R. rickettsii DNA

Question 11

Classic triad for RMSF?

Answer 11

1. fever
2. rash (extremities –> trunk)
3. headache

Question 12

Tx for RMSF?

Answer 12

Doxycycline

(tetracyclines)

MOA: inhibits binding of tRNA to 30s mRNA/ribosomal subunit

Question 13

Pathogens causing similar rash to RMSF?

Answer 13

Coxackie virus

T. pallidum (syphillis)

Question 14

Likely pathogens causing pericarditis?

Answer 14

Coxackievirus A or B

echovirus

Question 15

Differentiate between streptococcus species:

Answer 15

S. mutans (viridans, bovis):

• a-hemolytic–damage RBCs (looks green on augar)
• bacitracin resistant

S. pyogenes

• B-hemolytic – destro RBCs (looks clear on augar)
• bacitracin sensitive

Question 16

Coxackie A and B

group:

genomic material:

envelope?

Answer 16

Group IV,

ssRNA+

nonsegment

nonenveloped

icosahedral