Cholesterol drugs from PBL 4

Question 1

HM-CoA reductase inhibitors

prevent formation of mevalonate in cholesterol synthesis

Answer 1

statins

Question 2

Inhibits lipolysis in adipose tissue (catabolism of apo AI?)

reduces production of VLDL in liver

Answer 2

Niacin (vit B3)

Question 3

PPAR agonist

upregulates lipoprotein lipase, apo AI, AII

downregulates apo CIII (a lipolysis inhibitor)

Decreases VLDL

Increases HDL

Answer 3

fibrates

Gemfibrozil

Fenofibrate

Question 4

Blocks sterol transporter NPC1L1 in intestinal brush border

decreased delivery of intestinal cholesterol to liver.

Answer 4

Ezetimibe

Question 5

Binds to bile acids in the intestine and forms a nonabsorbable complex that is excreted in feces

results in increased conversion of cholesterol to bile acids in the liver

increased demand for cholesterol in liver cells, resulting in a compensatory increase in hepatic uptake (and thus systemic clearance) of circulating LDL-cholesterol.

Answer 5

Colestipol

bile acid sequestrant

Question 6

Chart in PBL 4 obj shows relative effects on LDL, HDL, TGL

Answer 6

look at it