Bolded info for Nordgren drugs Flashcards

1
Q

Positive effects of Nitrates/trites on cardiac O2 consumption:

A

decrease LV EDP

decrease preload

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

NTG should not be given with which drugs due to synergistic hypotension:

A

phosphodiesterase type 5 inhibitors

Vardenafil (viagra, cialis, ect)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Positive effects (with respect to angina) of Ca2+ channel blockers on cardiac O2 consumption:

A

increased coronary blood flow

decreased aortic diastolic pressure

decreased HR

decreased contractility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Positive effects (with respect to angina) of Beta blockers on cardiac O2 demand:

A

decreased aortic diastolic pressure

decreased HR

decreased contractility

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

most common cause of angina?

A

atherosclerosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Weak Beta blocker in Class IC?

A

Propafenone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Class IC with SLOW UNBLOCKING KINETICS?

A

Flecainide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Class IB with extra cardiac effect of significant chronic pain relief?

A

Mexiletine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Class IB used for Vtach

NOT ADVISED FOR PROPHYLAXIS

A

Lidocaine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Class IA

Loading dose NOT recommended

A

Disopyramide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Class IA

Toxicity = induction of TORSADES

A

Quinidine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Class IA

TORSADES + LUPUS-like syndrome

A

Procainamide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Why is “state dependance” useful in antiarrhythmics”?

A

Drugs bind preferentially to:
Activated (phase 0)
Inactivated (phase 2) channels

bind poorly to rested channels

so. …work best in tachycardia (lots of activations and inactivations per unit time)
- significant loss of resting membrane potential (many inactivated channels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Normal LV end systolic volume (Wigger’s):

A

60 mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Normal LV end diastolic volume (Wigger’s):

A

120 mL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly