Bolded info for Nordgren drugs Flashcards
Positive effects of Nitrates/trites on cardiac O2 consumption:
decrease LV EDP
decrease preload
NTG should not be given with which drugs due to synergistic hypotension:
phosphodiesterase type 5 inhibitors
Vardenafil (viagra, cialis, ect)
Positive effects (with respect to angina) of Ca2+ channel blockers on cardiac O2 consumption:
increased coronary blood flow
decreased aortic diastolic pressure
decreased HR
decreased contractility
Positive effects (with respect to angina) of Beta blockers on cardiac O2 demand:
decreased aortic diastolic pressure
decreased HR
decreased contractility
most common cause of angina?
atherosclerosis
Weak Beta blocker in Class IC?
Propafenone
Class IC with SLOW UNBLOCKING KINETICS?
Flecainide
Class IB with extra cardiac effect of significant chronic pain relief?
Mexiletine
Class IB used for Vtach
NOT ADVISED FOR PROPHYLAXIS
Lidocaine
Class IA
Loading dose NOT recommended
Disopyramide
Class IA
Toxicity = induction of TORSADES
Quinidine
Class IA
TORSADES + LUPUS-like syndrome
Procainamide
Why is “state dependance” useful in antiarrhythmics”?
Drugs bind preferentially to:
Activated (phase 0)
Inactivated (phase 2) channels
bind poorly to rested channels
so. …work best in tachycardia (lots of activations and inactivations per unit time)
- significant loss of resting membrane potential (many inactivated channels
Normal LV end systolic volume (Wigger’s):
60 mL
Normal LV end diastolic volume (Wigger’s):
120 mL