Control of movement Flashcards

1
Q

voluntary movement involves what higher centres ?

A
  • cerebral cortex
  • cerebellum
  • basal ganglia
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2
Q

what is idea ?

A

The idea is the supplementary motor area , the association areas and the limbic system

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3
Q

The program ?`

A

occurs in the primary cortex , premotor are and supplementary motor area

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4
Q

the execution ?

A

occurs in the pyramidal tract , extrapyramidal tract and motor neurone. From the execution you get movement of skeletal muscle

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5
Q

the feedback ?

A

occurs in the sensory systems , cerebellum , thalamus , basal nuclei and brainstem.

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6
Q

where does the voluntary motor impulses occur ?

A

in the pyramidal tract

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7
Q

where do they arise from ?

A

the motor area of the cerebral cortex

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8
Q

where do they snapse and what with ?

A

the motor neurones in the spinal cord.

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9
Q

what is decussation and describe in relation to movement ?

A

crossing over occurs as the axons from the pyramidal tract cross over in the medulla oblongata

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10
Q

what is the muscle innervation proportional to ?

A

complexity of the movement

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11
Q

what shape is the cerebellum and where is it located?

A

walnut shaped and at the back of the head

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12
Q

Although the cerebellum does not initiate voluntary movements what is it an important centre for ?

A

coordinating movements and for controlling posture and balance

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13
Q

in order to carry out these functions what does the cerebellum receive information from ?

A

the muscles , joints , skin , eyes , ears and parts of the brain involved in control of movement

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14
Q

why does ataxia occur and symptoms ?

A

the cerebellum starts to dysfunction this leads to symptoms such as include poor balance , being unsteady walking and the tendency to fall over. There is also an intention tremor that occurs due to poor adjustment of motor signal and oscillating movements occur which is a repletion of movements.

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15
Q

basal ganglia ?

A

collection of structures including the substantia nigra , corpus striatum , globus pallidus. They are involved in the initiation of movement , control of fine movement and coordination of movement.

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16
Q

what does the substantia nigra project inhibitory dopaminergic neurons to ?

A

the corpus striatum

17
Q

what does the substantia nigra recieve inhibitory GABAergic neurons from ?

A

the corpus striatum

18
Q

what does the corpus striatum have as inhibitory cholinergic interneurons ?

A

the cholinergic interneurones

19
Q

What does the corpus striatum project inhibitory GABAergic neurons to ?

A

the globus pallidus

20
Q

whatb does the Globus Pallidus project inhibitory GABAergic neurons to ?

A

thalamus

21
Q

what does the thalamus project excitatory glutamergic neurones to ?

A

the cortex

22
Q

what does the cortex project excitatory glutamergic neruones to ?

A

the spinal cord

23
Q

name 2 diseases of the basal ganglia ?

A

parkinson’s

Huntington’s

24
Q

symptoms of parkinson’s ?

A

involuntary tremor of resting muscles as well as muscle rigidity and weakness. There is also slowness of movements and difficulty stopping and starting movement. There is an 80% decrease in the dopaminergic neurons in the nigro-striatal pathway , this is the substantia nigra to striatum.

25
Q

what does the decrease in dopamine cause ?

A

decreased inhibition of striatal GABAergic inhibition

decreased inhibitory output from globus pallidus to thalamus.

26
Q

what do sufferers of PD also report up to 10 years before diagnosis ?

A

They often have different gut bacteria to healthy adults and report digestive issues

27
Q

what are the alpha - synuclein fibres like in healthy and compared to PD ?

A

in normal they are small and soluble , however in PD they clump together and damage the CNS

28
Q

is huntington’s normally genetic ?

A

yes

29
Q

why are the symptoms caused ?

A

symptoms are caused as there is a degeneration of the cholinergic neurons in the striatum and cerebral cortex. There is also degeneration of the GABAergic nerones in the striatopallidal (striatum to globus pallidus) and striatonigral (striatum to substantia nigra) pathways.

30
Q

treatment with L-dopa for PD , what is this ?

A

dopamine precursor

31
Q

carbidopa ?

A

prevents breakdown of dopamine and this increases the levels of dopamine as often they have decreased dopamine.