Complex Molecules

Question 1

These are proteins to which oligosaccharides are attached.

Answer 1

Glycoproteins

Question 2

Underlying mechanism by which GAGs allow for the formation of gel-like substance

Answer 2

Hydrogen bonding between gag chains

Question 3

I-cell disease is an autosomal recessive disorder caused by a deficiency of ______, which phosphorylates mannose residues to mannose-6-phosphate on N-linked glycoproteins in the Golgi apparatus within cells.

Answer 3

GlcNac phosphotransferase

Question 4

What is the only significant sphingophospholipid in humans?

Answer 4

Sphingomyelin

Question 5

Which glycerolphospholipids flips from the inner leaflet to the outer leaflet and is important in apoptosis?

Answer 5

Phosphatidylserine

Question 6

Which glycerophospholipids flips from inner leaflet to outer leaflet and is important in apoptosis?

Answer 6

Phosphatidylserine

Question 7

N-acetylgalactosamine + Glucuronic acid = ___________

Answer 7

Chondroitin sulfate

Question 8

What is the most abundant GAG?

Answer 8

Chondroitin sulfate

Question 9

What is the main GAG for the skin?

Answer 9

Dermatan Sulfate

Question 10

_____________ is a phospholipid , which is exclusively located in mitochondria , and has unique structure that consist of 2 phosphate residues and 4 kinds of fatty acyl chains.

Answer 10

Cardiolipin

Question 11

What refers to a large family of naturally occuring organic compounds characterized by multiples of phenol units?

Answer 11

Polyphenols

Question 12

Glucosamine + Iduronic acid= ______________

Answer 12

Heparin

Question 13

N-acetylgalactosamine + Iduronic acid= ______________

Answer 13

Dermatan sulfate

Question 14

Cause of mucopolysaccharidoses which are inherited lysosomal storage disease.

Answer 14

Defects in the degradation of GAGs in the proteoglycans

Question 15

In what organs heme is biosynthesized?

Answer 15

Liver and Bone marrow

Question 16

How many pyrrole subunits are there in a porphyrin molecule?

Answer 16

Four

Question 17

Pyrrole subunits in a porphyrin molecule are interconnected at their alpha-carbon atoms via ___________ bridges.

Answer 17

Methyne

Question 18

The porphyrin ring structure is dominantly ____________.

Answer 18

Aromatic

Question 19

Heme are porphyrins containing _____________.

Answer 19

Iron

Question 20

What is the committed step for porphyrin biosynthesis?

Answer 20

Formation of D-aminolevulinic acid (D-ALA)

Question 21

Consequence of acidification on the activity of hemoglobin caused when a malarial parasite invades a red blood cell.

Answer 21

There is a shift of a more T state

Question 22

Involves the oxidative cleavage of the porphyrin ring.

Answer 22

Catabolism of hemoglobin

Question 23

Upregulated protein in a patient presenting with hypogonadism and cardiomyopathy having juvenile hemochromatosis type 2A from a defect in the gene encoding hemojuvelin protein.

Answer 23

Hepcidin

Question 24

Form of hemoglobin that results due to a missense mutation in the B-globin gene that cause sickle cell anemia.

Answer 24

Precipitation of HbS molecules

Question 25

What is the cause of Niemann-Pick disease?

Answer 25

Is a lysosomal storage disease caused by a deficiency of sphingomyelinase.

Question 26

True about an Infant diagnosed with respiratory distress syndrome born pre-term at 28weeks of gestation.

Answer 26

The concentration of dipalmitoylphosphatidylcholine in the amniotic fluid is lower than that of a full-term baby.
Component of pulmonary surfactant.