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Musculoskeletal I > Collagen synthesis > Flashcards

Collagen synthesis Flashcards

1
Q

What is the most abundant protein in the body?

A

Collagen

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2
Q

What is the main component of collagen?

A

3 alpha polypeptide chains

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3
Q

What causes different types of collagen?

A

Variation in AA sequence of alpha chains

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4
Q

What are the two most common AAs in collagen?

A

Glycine
Proline

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5
Q

How often is glycine found in collagen alpha polypeptide?

A

Every third AA

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6
Q

What proteins are commonly found between two glycines in a collagen polypeptide?

A

Proline
Hydroxyproline or hydroxylysine

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7
Q

What is the importance of proline in the structure of collagen?

A

Ring structure causes kinks that help form triple helix

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8
Q

Why is the role of hydroxyproline in collagen?

A

Stabilize triple helix by H bonds

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9
Q

What is the role of hydroxylysine in collagen?

A

Role in glycosylation of collagen

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10
Q

What is the structure of Type I collagen?

A

Two alpha-1 chains
One alpha-2 chain

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11
Q

What is the structure of type II collagen?

A

Three alpha-1 chains

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12
Q

What are the three main groups of collagen?

A

Fibril forming
Network forming
FACITs

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13
Q

What are examples of fibril forming collagen?

A

Type I
Type II

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14
Q

What are examples of network forming collagen?

A

Type IV
Type VI

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15
Q

What are examples of FACITs collagen?

A

Type IX
Type XII
Type XIV

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16
Q

What are the main steps of collagen synthesis?

A

Preparo-alpha chains in rER
Signal sequence cleaved into pro-alpha chain
Hydroxylation in rER using vit C, iron and O2
Glycosylation in Golgi of some hydroxylysine
Procollagen from 3 pro-alpha chains
Packed into secretory vesicles
In ECM remove terminal propeptides releasing triple helical tropocollagen
Tropocollagen associate to form collagen fibrils
Cross-links formed

17
Q

What breaks down collagen?

A

Collagenases

Musculoskeletal I (14 decks)

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