Bone histology

Question 1

What are the functions of bones?

Answer 1

Support muscle attachment
Protection
Homeostatic regulation of blood calcium

Question 2

What are special components of bone ECM?

Answer 2

Type I collagen
Hydroxyapatite crystals

Question 3

What bones cells derive from mesenchymal stem cells?

Answer 3

Osteoprogenitors
Osteoblasts
Osteocytes

Question 4

What are osteoclasts derived from?

Answer 4

Hematopoietic stem cells

Question 5

What bone cells are found on the surfaces?

Answer 5

Osteoblasts
Osteoprogenitors
Osteoclasts

Question 6

What are the surfaces of bone?

Answer 6

Periosteum
Endosteum
Haversian canals

Question 7

What is needed to make osteoblasts out of osteoprogenitors?

Answer 7

BMP 6

Question 8

How to osteocytes perform cell-cell communication?

Answer 8

Numerous cytoplasmic processes though canaliculi that connect with gap junctions

Question 9

Where are osteoclasts found on bone?

Answer 9

In resorption bays/Howship’s lacuna

Question 10

What are the characteristics of immature bone?

Answer 10

Irregular arrangement of collagen, large number of cells, reduced mineral content

Question 11

What are the two types of mature bone?

Answer 11

Spongy
Compact

Question 12

What are the characteristics of compact bone?

Answer 12

Well organized lamellar structure of haversian system with cells organized regularly along same direction of lamellae

Question 13

What covers bone?

Answer 13

Periosteum

Question 14

What lines bone cavities?

Answer 14

Endosteum

Question 15

What is contained in endosteum?

Answer 15

Osteoprogenitors, osteoblasts, osteoclasts

Question 16

What is contained in Haversian canal?

Answer 16

Vascular and nerve supply

Question 17

What is contained in Volkmann canals?

Answer 17

Connect blood vessels and nerves from outer surface to Haversian canals