cocaine Flashcards
what are the three consumable forms of cocaine
coca laves
cocaine hydrochloride
free base cocaine - crack
what is the bioavilability of snorted cocaine
70%
what does dissolution of snorted cocaine create
HCl
how long is the onset for snorted cocaine
3-5 min
how long is the duration of snorted cocaine
30-40
what is the onset free base smoke
6-10 seconds
what is the duration of inhaled free-base
5-30
why can’t u smoke cocaine
it pyrolizes before it vaporizes
what temp does crack vapourize at
98 celcius
what is the onset of injected cocaine
10-15 second
what is the duration of injected cocaine
10-20
what is the major metabolite of cocaine
benzoylecgonine
what do liver and plasma esterases generate
ecgonine methylester
what is created by cocaine when co-administered with alcohol ?
cocaethylene metabolites
half life of cocaine
12 hr `
what percentage of metabolism is done by non-enzymatic hydrolysis
40%
which area of the brain can a high dose of cocaine affects
medulla
which NT underlies sympathiomimetic effects
NE
cocaethylene is a vaso__-
constrictor
what does benzos do with respect to cocaine
decrease NT release to assist with cardio
what does niutroglycerine do with respect to cocaine
NO release vasoconstrictive
IV treatment with ___ can elimiate cocaine
butrylcholinesterase
what signaling is chainged by cocaine use
opioidergic signaling`
what are the 3 treatments for cocaine
benzos, nitroglycerine,ice bath, butyrlcholinesterase
