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PMCOL 305 > 16. Sedatives and hypnotics > Flashcards

16. Sedatives and hypnotics Flashcards

1
Q

Which are more lipid soluble benzoate or barbituarar

A

Barbs

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2
Q

Half life of midazolam

A

2

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3
Q

Half life of diazepam

A

100

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4
Q

Where do benzos bind

A

Alpaca and gamma

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5
Q

Benzos vs barb receptor binding

A

Benzos = Allosteric that increase chloride channel opening
Barb = enhancr affinity and increase time that is is open

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6
Q

How does sedatives affect sleep

A

Total sleep time increased
REM sleep and resorative deep sleep reduced

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7
Q

How are overdoses treated

A

Flumazenil

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8
Q

How does tolerance work

A

Sedative and hypotonic
Slowly to anxiolytic
None for resp depression

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9
Q

How does GHB work

A

Agonist at GABA b precursor of GABA, GLU, GLY

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10
Q

what are z drugs

A

orexin antagonists, anti histamines, melatonin agonists

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11
Q

which drugs used for anesthesia

A

thiopental, midazolam, triazolam

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12
Q

which drugs are hypnotics used for sleeping

A

zopiclone, zolpidem

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13
Q

within the sedative class how are barbees and benzos categorized

A

duration of action

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14
Q

how are longer acting sedatives used

A

muscle relaxants, anticonvulsants, axiolytics

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15
Q

how are shorter acting sedatives used

A

pre anesthetics or insomnia

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16
Q

which has a slower onset of aciton

A

benzos

17
Q

are benzos and barbs bound to plasma proteins

A

yes

18
Q

do benzos sand barbs cross placenta

A

yes

19
Q

how are sedatives metabolized

A

CYP450

20
Q

what active metabolite does diazepam produce

A

chlordiazepoxide

21
Q

how many half lives for elimination

A

4-5

22
Q

where does GABA bind

A

between alpha and beta

23
Q

where are GABA with benzo binding sites located

A

limbic system, RAS, cortex

24
Q

do receptors that control respiration have benzo sites

A

nah

25
Q

which subunit is associated with short term memory

A

alpha

PMCOL 305 (19 decks)

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