CNS Transmission Flashcards
1
Q
What coverts tyrosine to L-DOPA?
A
tyrosine hydroxylase
2
Q
What converts L-DOPA to dopamine?
A
dopa decarboxylase
3
Q
What coverts dopamine to noradrenaline?
A
dopamine-beta-hydroxylase
4
Q
What converts noradrenaline to adrenaline?
A
phenyl-ethanolamine-N-methyl transferase
5
Q
What is the action of cocaine?
A
blocks neuronal uptake of noradrenaline, serotonin and dopamine and also blocks sodium channels
6
Q
What is the action of amphetamines?
A
indirectly acting sympathomimetic - displaces noradrenaline for non-exocytotic release
7
Q
What pathways is dopamine involved in?
A
movement, behaviour, dependence, pituitary function
