Alzheimer's Flashcards
1
Q
What are the pathological features of alzheimer’s disease?
A
amyloid plaques and neurofibrillary tangles
2
Q
What leads do amyloid plaques?
A
beta-amyloid cleaved from amyloid precursor protein
3
Q
Where are amyloid plaques?
A
extracellular
4
Q
What protein leads to neurofibrillary tangles?
A
tau
5
Q
Where are neurofibrillary tangles?
A
intracellular
6
Q
Which more closely correlates with degree of dementia - plaque burden or tangle burden?
A
tangle burden
