CNS Development Flashcards
what week gestation does CNS development begin?
3rd week post-conception
what influences formation of the brain?
genetics
intrauterine environment
extrauterine environment
what factors in the intrauterine environment can influence brain develop?
maternal health
placental delivery
insults during pregnancy e.g. alcohol
what factors in the extrauterine environment can influence brain development?
nutrition
environment
neglect
lack of stimulation
four stages of brain development
- embryonic
- foetal
- post-natal
- adolescent
what does the ectoderm form?
skin
nails
hair
neural tissue
what does the mesoderm form?
muscle
bone
cartilage
vascular system
what does the endoderm form?
gut
respiratory system
what day does the neural tube form?
day 20-27
what does signalling determine?
where the cells go and what they become
development of foetal brain
initially lissencephalic and gradually develops sulcal and gyral pattern
post-natal brain development
proliferation and migration with myelination
organisation needs diverse input
adolescent brain development
reorganisation of brain with many changes
what can result if insults happen during neural tube formation?
anencephaly
spina bifida
what can result if insults happen during development of brain vesicles?
holoprosencephaly (forebrain doesn’t develop into two hemispheres)
