Clinical Pharmacology Flashcards
what may happen in the immediate post natal period?
problems may arise through in utero exposure and transplacental transfer of drugs to the infant
key points the prescribing for children?
When prescribing drugs for children use the most simple dosage regimen.
Pay attention to formulation, route, and duration of therapy.
Involve parents in your prescribing choice
Always check with the BNFc
why are there problems with medicines In children? (4)
- Pharmacokinetic differences between adults and children
- Altered pharmacodynamic responses
- Effects on growth and development not known
- Different specific pathologies
what is licensed in infants with persistent pulmonary hypertensionofnewborn(PPHN?
Sildenafil
CYP1A2 - peak activity?
20 years
- reduced metabolic enzyme activity in children
preterm and premature is if a baby is?
less than 36 weeks
the early post natal period (0-27 days) - babies have physiological immaturity with ???
- rapid growth
- highly variable alterations in drug metabolism and elimination.
- lower tolerance to ADRs,
difficulty in identifying efficacy and toxicity.
the young child has what differences in their drug uptakes?
- Enhanced metabolism and excretion
- Clearance can change significantly during a single dose regimen.
Absorption via the GIT reaches adult values ?
6-8 months.
Reduced gastric acid and delayed gastric emptying. Adult levels reached at 3 years
