clinical pathological conference of ovaries

Question 1

What are the genes which increase risk of ovarian cancer

Answer 1

HNPCC/Lynch type II familial cancer syndrome

BRCA 1

BRCA 2

P53

Question 2

What mutations are associated with endometroid carcinoma

Answer 2

ARID1A

PIK3CA

PTEN

Question 3

What are the vague symptoms of ovarian cancer

Answer 3

Indigestion

Poor appetite

Altered bowel habit

Bloating

Discomfort

Weight gain

Pelvic mass

Question 4

How is ovarian cancer diagnosed

Answer 4

Surgical diagnosis or a tissue guided biopsy

Question 5

What are the investigations done for suspected ovarian cancer

Answer 5

Surgery, Biopsy, Ultrasound abdo and pelvis, CT scan, CA 125

Question 6

What is CA 125

Answer 6

Glyco-protein antigen which is raised when ovarian cancer is present but it is also raised with colon, pancreas and breast cancer

Question 7

Describe the stages of ovarian cancer

Answer 7

Stage 1 – confined to ovary

Stage 2 – both ovaries and in pelvic area

Stage 3 – in abdominal cavity

Stage 4 - distant metastasis

Question 8

What is PARP

Answer 8

An enzyme that helps cancer cells repair