clinical 7 Flashcards

1
Q

when do you give thrombolylis in stroke

A

within 4.5 hours of onset of symptoms

once haemorrhage stroke has been ruled out

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2
Q

preventative drug given after an ischaemic stroke

A

clopidogrel

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3
Q

what do you give after an ischaemic stroke if clopidogrel is CI

A

aspirin plus modified release (MR) dipyridamole

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4
Q

facial nerve innervates what 4 areas

A

face - facial expression
ear - nerve to stapedius
taste - anterior 2/3rds
tear - lacrimal gland

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5
Q

Causes of bilateral facial nerve palsy (4)

A

sarcoidosis
Guillain-Barre syndrome
polio
Lyme disease

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6
Q

cholesterol level that requires statin after an ischaemic stroke

A

if more than 3.5

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7
Q

anti epileptic most associated with weight gain

A

sodium valproate

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8
Q

how does sodium valproate work

A

increases GABA activity

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9
Q

first line treatment for generalised seizures

A

sodium valproate

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10
Q

first line treatment for partial seizures

A

carbamazepine

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11
Q

second lin treatment for generalised if sodium valproate is not working

A

lamotrigine

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12
Q

carbamazepine may actually exacerbate ______ seizure

A

absent

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13
Q

frequency of migraine that requires prophylaxis

A

more than 2 a month

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14
Q

migraine prophylaxis in woman of child bearing age

A

propanolol

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15
Q

migraine prophylaxis in the with asthma

A

topiramate

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16
Q

drug that can be given as migraine prophylaxis

A

topiramate or propanolol

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17
Q

when do you give phenytoin

A

in status epileptics is continuing 10 mins after receiving diazepam or lorazepam

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18
Q

what can happen following a sub arachnoid haemorrhage

A

cerebral vasospasm

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19
Q

what do you give following a subarachnoid haemorrhage to prevent cerebral vasospasm

A

calcium channel blocker (ends in -pine)

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20
Q

if stroke due to a-fib, when do you start anticoagulation therapy (warfarin)

A

15 days after onset of symptoms

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21
Q

first line for spasticity in MS

A

baclofen or gabapentin

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22
Q

whig parkinson drugs make you lose impulse control

A

dopamine agonists

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23
Q

what is ‘anticipation’ in huntingtons

A

earlier onset in successive generations

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24
Q

drug that can cause parkinsinism

A

haloperidol (antipsychotic: decrease amount of dopamine, low dopamine associated with parkinson)

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25
Q

first line treatment for neuropathic pain

A

amitriptyline, duloxetine, gabapentin or pregabalin

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26
Q

first line treatment for trigeminal neuralgia

A

carmabazepine

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27
Q

bells palsy, what nerve

A

facial LMN

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28
Q

what is radiculopathy

A

nerve impingement/lesion at level of spine

29
Q

‘triptan sensation’

A

tingling, heat, tightness (e.g. throat and chest), heaviness, pressure

30
Q

moraine treatment in pregnancy

A

1st line: paracetamol

2nd: aspirin or ibuprofen is in 1st or 2nd trimester

31
Q

who don’t you give neuroleptics (i.e. haloperidol) to and why

A

lewy body because it can cause non reversible parkinsonism

32
Q

how can you differentiate parkinson from drug induced parkisonism

A

do not get rigidity and resting tremor in drug induced

33
Q

acute migraine treatment

A

oral triptan + NSAID or titan + paracetamol

34
Q

what makes essential tremor better

A

alcohol and propanolol

35
Q

treatment for essential tremor

A

propanolol

36
Q

anti body present 25% of people with Guillain-Barre syndrome

A

anti-ganglioside antibody (e.g. anti-GM1)

37
Q

bilateral acoustic neuromas - what condition

A

neurofibromatosis type 2

38
Q

neurofibromatosis type 2 inheritance and chromosome

A

autosomal dominant and is an inherited defect in chromosome 22.

39
Q

Neurofibromatosis type 1 is due to a mutation in chromosome ___

A

17

40
Q

tuberous sclerosis is often associated with a mutation in chromosome ___

A

16

41
Q

what will indicated neurofibromatosis 1 rather than 2

A

Café-au-lait spots (>= 6, 15 mm in diameter)

Axillary/groin freckles

42
Q

what will indicated neurofibromatosis 2 rather than 1

A

bilateral acoustic neuromas

43
Q

dopamine agonists end in

A

-ine(Bromocriptine, cabergoline, apomorphine)

44
Q

what is dystonia

A

sustained, abnormal posture cased by persistent contraction of large trunk or limb muscles

45
Q

what is blepharospasm

A

twitch or spasm of eye

46
Q

what is hemiballismus

A

uncontrolled flailing of limbs - lesion or dysfunction of subthalmic nucleus

47
Q

nerve root level if weakness in knee extension and ankle dorsiflexion

A

L4

48
Q

parts of peripheral nervous system that carries parasympathetic nerve fibres

A

craniosacral out flow: cranial nerves III, VII, IX, X and anterior rami of sacral spinal nerves which enter PELVIC splanchnic nerves

49
Q

roots carry what fibres

A

just motor or just sensory

50
Q

what carries both sensory and motor fibres

A

rami

51
Q

wha makes up brachial plexus

A

anterior rami of C5 - T1

52
Q

calcimine sulcus located where

A

occipital lobe (part of visual pathway)

53
Q

what is galantamine

A

cholinesterase inhibitor

54
Q

oliclonal bands are seen in what condition

A

MS - seen in gel of CSF (also get high lymphocytes)

55
Q

receptive aphasia

A

wernicke’s (temporo-parietal area)

56
Q

expressive aphasia

A

brocas (frontal lobe)

57
Q

what is nominal aphasia

A

not being able to name familiar objects

58
Q

middle cerebral artery supplies where

A

lateral aspect of parietal lobe

59
Q

lateral aspect of parietal lobe is supplied by which artery

A

middle communicating

60
Q

anterior cerebral artery supplies where

A

anterior corpus collosum and superior frontal gyrus

61
Q

posterior cerebral artery supplies where

A

poseroventral nucleus of thalamus and inferior temporal gyrus

62
Q

in brown squared syndrome at what level with pain and temp be lost

A

3 levels below the spinal lesion

63
Q

part of brain responsible for memory, emotional reaction and decision making

A

amygdala

64
Q

what ligament does an epidural needle pass through

A

filamentum flavum

65
Q

level of epidural

A

L3/L4

66
Q

what level does the spinal cord end

A

L2

67
Q

subarachnoid space ends at what level

A

S2

68
Q

dura that covers cerebellum

A

tentorium cerebelli

69
Q

what causes a ‘blow pupil’

A

compression of oculomotor nerve by an uncal herniation