Class 4 Flashcards
What are viral infections/virus?
• Viruses are smallest obligate intracellular pathogen.
• no organized cellular structure.
• consist of protein coat (a.k.a. capsid) surrounding
nucleic acid core of RNA or DNA.
• some enclosed within lipoprotein envelope derived from cytoplasmic membrane
of parasitized host cell.
How do viruses work?
• viruses incapable of replication outside a living cell
• virus will attach to host cell, enter it, then release its genetic material
• replicates immediately or can remain dormant for extended period of time
• host cell usually dies then virus can release viral replications, which can go on to infect other cells
What are routes of viral infection?
• Nasal & respiratory
• Oral & gastrointestinal
• Through blood & bodily fluids (needles, bites, STI’s)
What is the body’s response to viral infections?
• Inflammatory response – vascular congestion & leakage
of exudate
• Immune response – collection of lymphocytes in infected tissue
-Medical treatment is supportive, may involve use of
anti-viral drugs
-Prevention is by IMMUNIZATION
What is Inflammatory response to viral infections?
vascular congestion & leakage of exudate
What is Immune response to viral infections?
collection of lymphocytes in infected tissue
What is Poliomyelitis?
• acute viral infection, can affect nervous system.
• may lead to full or partial paralysis.
• caused by poliovirus
• 2 types: paralytic & non-paralytic
• highly contagious, can spread by contact with infected mucous, phlegm or feces through mouth & nose.
• multiplication occurs in lymphoid tissue of throat & GI tract then invasion of CNS.
• incubation period is 5-35 days.
• can be prevented with immunization.
What is Rubeola (Measles)?
• highly contagious respiratory infection
• caused by paramyxovirus
• causes total body skin rash with flu like symptoms (fever, cough, & runny nose)
• treatment is palliative
• prevented with immunization
What are the 2 types of Poliomyelitis?
• paralytic - more severe (full paralysis)
• non-paralytic - flu like symptoms (partial paralysis)
What is Rubella (German Measles)?
• caused by rubella virus
• primarily affects skin & lymph nodes
• spread by inhaling infected droplets
• can pass through placenta from mother to
fetus, lead to CONGENITAL RUBELLA SYNDROME which may lead to visual & hearing impairments, heart disease, spleen, liver, bone marrow abnormalities, & thrombocytic purpura (BLUEBERRY MUFFIN RASH)
• symptoms include fever, headache, general malaise, runny nose, skin rash are more severe in adults than children
• infection results in lifelong immunity
• prevented with immunization
What is mumps?
• highly contagious viral infection, spread through saliva.
• primarily affects parotid glands.
• S/S fever, headache, arthralgia, loss of appetite, followed by pain & swelling of parotid glands.
• uncommon under 12 months old
• first infection will yield lifelong immunity
• treatment aimed at reducing pain
What is Chicken Pox?
• common, preventable childhood infection caused by Varicella-Zoster virus.
• usually mild, but uncomfortable in children & more severe in adults.
• spreads by direct contact & droplet transmission
• can spread to fetus from infected mother
• S/S fever, followed by itchy rash changes to fluid filled blisters which break & scab
• most cases result in lifelong immunity
• prevented with immunization
What is Shingles aka zona aka Herpes-Zoster?
• not a childhood illness
• only occurs in people who have had chicken pox
• remains dormant in dorsal root ganglia for years
• usually activated by stress.
• less contagious, does not spread through droplet transmission
• leads to acute CNS infection involving primarily
DRG.
• S/S include neuralgic pain & vesicle eruption on
skin which resembles chicken pox but presents in dermatomal pattern consistent with DRG in which virus was dormant.
• if you’re susceptible to Chicken Pox (meaning you are not immune/did not get vaccine) you can catch Chicken Pox from Shingles BUT YOU CAN’T catch Shingles from Shingles
What is the Common Cold?
• mild infection of upper respiratory tract.
•caused by several different viruses including rhinovirus, adenovirus & coronavirus.
• S/S are sneezing, stuffy nose, sore throat, coughing
• lasts between 2-14 days
• highly contagious, can spread by droplets. sneezing/coughing by direct or indirect contact.
What is Influenza (The Flu)?
• viral infection of lower respiratory tract
• mild or life threatening
• 3 types of influenza virus – A, B, & C & are further sub-categorized based on
2 surface antigens: hemagglutinin & neuraminidase (DW). Ex. of Types A Influenza include H1N1, H5N1, & H3N2.
• occurs every 2-3 years in epidemics.
• high mortality rate among elderly
• S/S are chills, fevers, headache, arthralgia, sore throat, cough
• can lead to life threatening complications & secondary infections like pneumonia
• spread in same manner as common cold
• influenza virus is constantly mutating, giving rise to different
antigen presentations.
What is SARS?
• Severe acute respiratory syndrome (SARS) illness caused
by new form of coronavirus. Thought to have originated in civets (type of cat) in China. spread by close person to person contact
• S/S initially presents with cold like symptoms, high fever is
key diagnostic sign then spreads to lower respiratory tract
causing pneumonia that’s fatal in 10% of cases
• Treatment is palliative with special attention to reduction of
fever
• No vaccines or specific medications available; O2 supplied as
needed
What is MERS?
• Middle East respiratory syndrome (MERS) is new SARS like
virus.
What is Intestinal Flu (viral enteritis, gastroenteritis – Con Al – while names are similar, this is not same as influenza)?
• most common type of gastrointestinal infection
• spread through contaminated food or water & dreaded
fecal oral route.
• more common in children
• lasts 1-2 days (sometimes called 24-hour flu)
• S/S are nausea, vomiting, diarrhea, malaise, low grade fever,
abdominal pain
• treatment is palliative
There are 2 types of herpes infections. What is Type 1?
• causes oral & skin lesions on or near lips called “cold sores” or “fever blisters”
• after initial infection, virus stays dormant in nerve cells
• flare ups are precipitated by stress or febrile illness
• transmitted by direct contact
• can cause encephalitis
There are 2 types of herpes infections. What is Type 2?
• causes genital infection
• stays dormant in nerve cells after initial infection
• may be transmitted during childbirth
• can produce fatal disseminating neonatal infection
What is Human Papilloma Virus (HPV)?
• more than 100 types of HPV, most are harmless & just cause warts (verrucae).
• only 30 types give risk of cancer, these types usually affect
genitals & spread through sexual contact
• warts cause proliferative lesions of squamous epithelium.
• associated with increased risk of developing cervical cancer & in recent years there has been an increase in oral & pharyngeal cancers in men.
•’there is preventable vaccine
What is Mononucleosis (the kissing disease)?
• caused by Epstein-Bar virus.
• saliva is primary method of transmission can also be spread by coughing, sneezing or sharing infected eating utensils/drinking glasses
• incubation period is 4-6 weeks
• S/S fever, sore throat, generalized lymphadenopathy,
lethargy, splenomegaly, hepatitis, & atypical lymphocytes.
• lasts for weeks sometimes months to years.
• more common amongst teenagers & young adults
• virus remains in body, can become active without symptoms later in life
What is Human Immunodeficiency Virus (HIV)?
• virus leads to Acquired Immune Deficiency Syndrome (AIDS).
• spread by contact with infected bodily fluids (blood/semen)
• first presents with mild flu like symptoms then lies dormant for years
• when it reactivates, it attacks T-cells
• as T-cells die, immune system looses ability to defend body against infection
• death was due to pneumonia or other opportunistic infections
• now medications that have made HIV no longer a
death sentence
What is Viral Hepatitis?
-diffuse inflammatory disease of liver.
-caused by several different viruses
-S/S are nausea, vomiting, malaise, fever, headache, dark urine,
jaundice, enlarged liver, excess bruising, and pain in abdomen.