Class 22 Flashcards
Systems Complications (Cardiovascular) Hypertension
→ result of combined effects of heart & blood vessel changes & lung, liver, kidney stresses
Systems Complications (Cardiovascular) Large Vessel Damage (diabetic macroangiopathy)
→ increased incidence of atherosclerosis
→ thickening from irritation/damage of vessel walls
(arteriosclerosis)
→ onion-skinning: recurrent internal scarring, from
high blood pressure & blood pH
Systems Complications (Cardiovascular) Small Vessel Damage (diabetic microangiopathy)
Hyalinization is form of tissue degeneration in which normal tissue components deteriorate & there is excess production of extracellular matrix. Result is homogeneous & glassy material. Arteriolar hyalinization is like onion skin lesion in arteries, forming in layers in tunica media (smooth muscle
layer) sometimes also endothelium basement membrane &/or adventitia layer. It results in reduced lumen size & loss of contraction/dilation capacity of vessel wall. Similar degenerative process can occur in cells of capillary walls, making them stiff & impenetrable, also resulting in poor myoepithelial response (ability to change size of pores between cells). Results in ↓tissue nutrition/function, ↑ TPR, edema.
Systems Complications (Cardiovascular) Heart Damage (overlaps with other vital organ stress)
→ heart wall perfusion is reduced
→ cardiac muscle glucose supply is compromised
→ coronary arteries strongly affected by atherosclerosis
→ heart is stressed by hypertension
→ body tissue needs lead to increased demands on heart
→ congestive heart failure develops
Systems Complications (Cardiovascular) Increased Risk of Infarction
→ tissue death due to loss of blood supply
→ can occur in various locations
→ diabetics have higher incidence of angina pectoris & heart attack, & TIAs & stroke than non-diabetics
Damage to cardiovascular system is now understood to start at __________________________.
prediabetes stage, so before diabetes diagnosis.
Up to 80% of people with diabetes die of ________________ (compared to 50% in the general population).
CV disease
After having stroke or heart attack, people with diabetes are at ↑’d risk of having ___________________ or __________________compared to non-diabetics. People with diabetes are also more likely to need an angioplasty.
second stroke or heart attack
Studies have shown that CV system of adults with Type 2 diabetes may have?
impaired ability to adapt to exercise. MRI scans showed that teens with Type 2 diabetes had hearts that did not expand & fill with blood to same capacity as those without diabetes. Teens were also shown to have less blood flow through femoral arteries.
Study at Heart & Diabetes Research Institute in Melbourne, Australia found correlation between?
insulin resistance & increased sympathetic nervous system activity. This is because of multiple changes in beta 2 & beta 3 adrenoceptor genes. SyNS activity accompanying insulin resistance is closely linked with left ventricular hypertrophy in patients with Type 2 diabetes, even those without high blood pressure.
After 10-15 years, all diabetics have ___________________________.
some degree of CV impairment
(Diabetes) Increased Risk of Gangrene
→ 100 times more likely to occur in diabetic
→ may develop from minor injury/wound
→ combined effects of poor tissue resilience, toxic conditions, impaired perfusion/ drainage, tendency to infection
→ risk of amputation, especially in lower limb
(Diabetes) Kidneys
→ high incidence of renal artery atherosclerosis
→ high incidence/recurrence of kidney infections & stones
→ adversely affected by hypertension
→ very damaged by diabetic micorangiopathy
→ their blood supply & nutrient supplies compromised
→ nephritic & nephrotic syndromes
→ glomerulonephron destruction
→ high incidence of kidney failure
(Diabetes) Vision
→ impaired eye tissue health, susceptibility
to infection, impaired extrinsic & intrinsic circulation
→ high incidence of microbleeds
→ potential for impaired neurological controls
→ increased incidence of cataracts &
glaucoma
→ vision impairment of some degree is typical
→ significant incidence of both legal & total
blindness
(Diabetes) Liver
→ extremely high workload under adverse conditions
→ blood supply, glucose & enzyme supplies compromised
→ adversely affected by hypertension
→ high incidence of liver damage
(Diabetes) Digestion
→ digestive problems show up pervasively
→ combinations of indicators of poor digestion & elimination, with nausea & diarrhea prominent
→ digestive structures can be uncomfortable, painful
(Diabetes) Skin
→ reduced cellular health/resilience
→ compromised local circulation, especially in extremities
→ increased susceptibility to bacterial & fungal infection
→ increased risk of injury due to sensory deficits
→ increasing tendency to breakdown, ulceration
Nervous System (Central Nervous System)
→ seizures (usually from non-compliant behaviour)
→ various impairments of body system controls
→ increased tendency to develop dementia