Chronic Inflammation

Question 1

List the cell types involved in chronic inflammation

Answer 1

Lymphocytes
Macrophages
Plasma cells
Fibroblasts

Question 2

List the major causes of chronic inflammation

Answer 2

Arising from acute inflammation:

Arising as a primary lesion

Question 3

How does chronic inflammation arise from acute inflammation?

Answer 3

• Large volume of damage
• Inability to remove debris
• Fails to resolve

Question 4

How does chronic inflammation arise as a primary lesion?

Answer 4

-No acute phase
-Can be a result of
>AUTOIMMUNAL DISEASE eg autoantibodies are directed against own auto antigens. Example- thyroiditis, rheumatoid disease
>MATERIAL RESISTANT TO DIGESTION eg mycobacteria, viruses
>EXOGENOUS SUBSTANCES eg sutures, glass
>ENDOGENOUS SUBSTANCES eg keratin, hair, necrotic tissue

Question 5

Describe the effects of chronic inflammation

Answer 5

• Scarring and fibrosis

- Granuloma formation

Question 6

What are the adverse effects of chronic inflammation

Answer 6

• ongoing tissue or organ damage

- incidious loss of function

Question 7

What are the roles of macrophages?

Answer 7

Take over from neutrophils and remove debris.
Main antigen-presenting cells
Contains enzymes and product interferons and other chemicals which destroy the process