Chronic Inflammation Flashcards

1
Q

Chronic Inflammation

A

Vasodilation
Blood clotting
Oedema
Recruitment of immune cells

Signs:
Redness
Heat
Oedema
Pain

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2
Q

Chronic Inflammation: Pathophysiology

A

Cytokines (TNF-a, Il-1,6)
Histamine
Kinins
NF-kB
PGE-2

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3
Q

Chronic Inflammation: Eicosonaids

A

Hormone-like messagers made by oxidation of omega 3 and 6 fats.

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4
Q

Inflammation resolution

A

T-Reg cells
PGE-1 and 3, Resolvins and protectins

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5
Q

Chronic inflammation: Causes and risk factors

A

Refined sugar
High Omega 6/3 ratio
FADS1,2 polymorphisms
Obesity
Chronic stress
Sleep
Over-exercise
Oxidative stress
Toxic load
Metabolic endotoxaemia
Persistant or latent infection

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6
Q

Chronic Inflammation: Supplements

A

COPED GB

Curcumin
OPCs
Plant sterols
EFAs
Vitamin D

Ginger
Boswelia

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7
Q

Chronic Inflammation: Curcumin

A

Il-6, TNF-a

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8
Q

Chronic inflammation: OPCs

A

COX-2

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9
Q

Chronic inflammation: Plant sterols

A

Il-6, TNF-a

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10
Q

Chronic Inflammation: EFAs

A

Il-6, TNF-a

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11
Q

Chronic Inflammation: Vitamin D

A

T-reg - immunomodulator
Il-6, TNF-a

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12
Q

Chronic Inflammation: Ginger

A

Cox-2

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13
Q

Chronic Inflammation: Boswelia

A

Pain
5-Lox

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