Autoimmunity

Question 1

Autoimmunity

Answer 1

Immune system mistakenly attacking self.
Breakdown in self tolerance

Question 2

Autoimmunity: Pathophysiology

Answer 2

Tolerance: Untrained t-cells, too few t-reg cells
Balance: Th1: Th2 balance. Th1 and Th17 - > most autoimmune. Th2 -> SLE
Cross-reactivity: mimicry and tissue damage, micro-organisms, food (gluten, dairy)

Question 3

Autoimmune: Major Histocompatibility Complex

Answer 3

MHC: encodes cell surface proteins (HLAs) and identifies self

Dysfunction -> autoimmune

Question 4

Autoimmune and Micro-organisms

Answer 4

EBV: RA, MS, SLE
Strep: Psoriasis
E.Coli, Clostridium difficile: IBD
Klebsiella: Ankylosing spondylitis, RA
Yersinia: Graves and Hashimoto

Question 5

Autoimmunity: Causes and risk factors

Answer 5

HLA SNPs
Emotional trauma
Gluten
Toxins
Vit D deficiency
Dysbiosis
Permeability
Female

Question 6

AI: Supplements

Answer 6

RACED

Resveratrol
Alpha Lipoic Acid
Curcumin
EFAs
Vitamin D

Question 7

AI: Resveratrol

Answer 7

Reduce TH-17
NF-kB
Cox-2

Question 8

AI: Alpha Lipoic Acid

Answer 8

Antioxidant
Anti-inflammatory
Raises glutathione

Question 9

AI: Curcumin

Answer 9

TNF-a
Il-6

Question 10

AI: EFAs

Answer 10

PGE-2

Question 11

AI: Vitamin D

Answer 11

T-reg activity

Question 12

AI: SLE

Answer 12

Systemic Autoimmune Response Th2

Butterfly skin rash
Joint inflammation and fatigue

Pathophysiology: defective clearance of cell debris -> immune response