Chloramphenicol - antimicrobial

Question 1

MOA

Answer 1

inhibits protein synthesis by binding to ribosomes

bacteriostatic - time dependant

Question 2

Use indications

Answer 2

• gram +ve and gram -ve (eg pasteurella. Mannheima, Histophilus)
• Used in dogs for eye treatment (crosses cornea), CNS, heart, lung, saliva, prostate, foetus, milk

Question 3

Spp application

Answer 3

Banned in food producing animals

but is registered for cattle and pigs

Question 4

Representative drugs

Answer 4

• Florenfenicol - no aplastic anaemia - registered in cattle and pigs

Question 5

PK quirks

Answer 5

• Very high lipophilicyt - the go anywhere drug.
• metabolised in the liver
• florfenicol has high bioavailability