Beta lactase - Cephalosporins

Question 1

MOA

Answer 1

Inhibits cell wall synthesis

Question 2

Use indications

Answer 2

1st gen = cephalexin (used for skin infection - pyoderma) and cefazolin (used in foals)- less anaerobic activity but excellent against Staph

2nd gen = expansed gram -ve activity but is less active against gram +ve e.g. enterobacter

3rd gen = ceftiofur (very important for septicaemia) - further improved gram -ve e.g. E.coli (Nil milk WHP)

Question 3

Side effects/contraindications

Answer 3

hypersensitive (allergic) reactions. If given PO it can cause anorexia, vomoting, diarrhoea

Question 4

PK quirks

Answer 4

Same as pen i.e
weak acids - pH partitioning
Good distribution except! the eye, lung, abscesses, prostate etc
renal elimination