Chlamydia and Chlamydophila Flashcards
1
Q
Physical description of organism
A
- obligate intracellular parasite
- small genome; lacks metabolic genes and steals ATP
2
Q
Cell wall of organisms
A
- lacks MurNAc(not true PG), but has PBPs
- 15 servers based on LPS antigens
3
Q
Type of host cells
A
- eukaryotic host cells
- embryonated chicken eggs
- McCoy cells in monolayer tissue
- mouse brains
4
Q
Two forms involved in the life cycle of organism
A
Elementary bodies and Reticulate bodies
5
Q
Basic description of both forms
A
- elementary bodies: infective
- reticulate bodies: replicative
6
Q
Description of elementary bodies
A
- 0.3um diameter
- electron dense nucleoid
- tough membrane w/S-S
7
Q
Description of reticulate bodies
A
- 1.0um diameter
- diffuse EM staining
- fragile w/SH HS
- more ribosomes
8
Q
Clinical presentation of organism
A
- Trachoma
- infection at birth from infected canal or contact or vector
- mucopurulent discharge, pannus formation(keratnized cornea), cornea obscuration and eyelid involvement(trichiasis)
- irritation from eyelashes+pannus+bacteria lead to blindness
9
Q
Clinical presentation of organism
A
- Inclusion conjunctivitis
- similar to trachoma, not severe
- neonate from infected birth
- associated respiratory comps.
10
Q
Clinical presentation of organism
A
- Neonatal pneumonia
- shortness of breath, no fever
- occur in newborn with incl. conjun.
11
Q
Clinical presentation of organism
A
- Chlamydia
- STD
- Males
a. nongonococcal urethritis
b. epididymitis
c. prostatitis
d. normally self limiting
- Females
a. urethritis
b. cervicitis
- salpingitis/PID
12
Q
Clinical presentation of organism
A
- Latent infection(lymphogranuloma venereum)
- small abscess, and initially heals quickly
- inguinal buboes follow
- fever and pain
- may turn black, never cervical LN
- may become chronic lead to fibrous lymphatic restrictions or bowel obstructions
13
Q
Epidemiology of organism
A
- STD most common type in NA, SA, Eur
- Trachoma common where hot, dry areas with poor clean water
14
Q
Pathogenesis of organism
A
- invasivness is caused by elementary bodies, binding to host receptor
- pathogen mediated endocytosis via T3SS effectors that remodel cytoskeleton
- induce cytokines, IL1 and cause inflammation
- tend to remain in host cells
15
Q
Control of organism
A
- vaccine ineffective
- screening is key, PCR common
- azithromycin
- surgery or epilation for trichiasis
- tetracycline or macrolides
16
Q
Description of C. pneumoniae
A
- jumped to humans as a zoonosis from koalas?
- high infection rate but most asymptomatic
- mild URT disease may progress
- found in atherosclerotic plaques
- asthma, stroke, Alzheimers
- tretracycline might help
17
Q
Description of C. psittaci
A
- acute, severe pneumonia and sepsis with patchy, well-defined lung involvement
- always transmitted by contact with birds
- tetracycline
