Campylobacter Flashcards
1
Q
Physical description of bacteria
A
- Gram negative
- curved, helical, gull winged
- polar flagella, sometimes bipolar
2
Q
Type of bacteria
A
- microaerophile(reduced O2 concentration)
- use growth temperature to differentiate species
3
Q
Temperature and number of bacteria of C. Jejuni
A
- organism grows at 42C, but not 25C
- infection requires 10^4 orally
4
Q
Organ that is affected most by C. Jejuni
A
large intestines
5
Q
Clinical presentation of C. Jejuni
A
- abdominal pain(gastroenteritis)
- cramps, fever, very bloody diarrhea
- may invade bloodstream and cause enteric fever
- self limiting within a week
6
Q
Sequela of C. Jejuni
A
- 1 to 4 wks after C. Jejuni
- Guillain-Barre syndrome
- autoantibodies to Gm1 gangliosides
7
Q
Epidemiology of C. Jejuni
A
- zoonosis
- human acquisition via fecal oral route
- consumption of contaminated poultry or milk
- most common in infants and young adults
8
Q
Pathogenesis of C. Jejuni
A
- produces an inflammatory enterotoxin
- bacteremia indicates an invasive potential
9
Q
Control of C. Jejuni
A
- rehydration therapy to treat diarrhea
- tetracycline, quinolones, clarithromycin
10
Q
Clinical presentation of C. Fetus
A
- grows at 25C but not at 42C
- systemic infections, septicemia(rarely diarrhea)
11
Q
Epidemiology of C. Fetus
A
- zoonosis(naturally in animals, transmission to humans)
- acquire from eating contaminated undercooked beef
- elderly, ill, and immunosuppressed
12
Q
Pathogenesis of C. Fetus
A
- major virulence factor is an S-layer protein
- S layer protein inhibits complement fixation by C3b; less opsonization so less phagocytosis
13
Q
Control of C. Fetus
A
-tetracyclines, macrolides, quinolones
