Brucella Flashcards
1
Q
Physical description of Brucella
A
- G negative
- aerobic
- coccobacillus
- very slow growth
- facultative intracellular parasite
- goats, cattle, swine, dog
2
Q
Clinical presentation of brucella
A
- incubation 1-6wks
- undulant fever
- chronic with intracellular localization, granuloma(liver, spleen, LN, bone)
- livestock abortions
3
Q
Epidemiology of brucella
A
- abortion storms
- transmitted from male in semen
- wild animals
- milk, infected animals, lab accidents
4
Q
Pathogenesis of brucella
A
- intracellular survival of PMNs and macrophages
- spreads by lymphatics and bloodstream
- no exotoxin, response to LPS, PG, cytokines
5
Q
Control of brucella
A
- pasteurize milk
- doxycycline + rifampin, streptomycin
- erradication from herds
