Chapter 9 Flashcards
metabolism
network of chemical processes that maintain life
metabolic pathway
biochemical reactions that occur in progression from beginning to end
intermediates/metabolites
compounds formed in pathway
anabolic
pathways that build compounds
catabolic
pathways that break down compounds
ATP
body’s source of energy derived from catabolic reactions
What is ATP broken down into?
ADP or AMP to generate energy
1 st stage of catabolism
Digestion: breakdown of complex molecules t their component building blocks
2nd stage of catabolism
conversion of building blocks to acetyl-coA
3rd stage of catabolism
metabolism of acetyl-coA to CO2 and formation of aTP
Oxidation-reduction reactions
electrons are transferred through reactions from energy yielding compounds to oxygen
loses electron (gains oxygen or loses hydrogen
oxidized
gains electron
reduced
compounds that facilitate enzyme activity and carry electrons
coenzymes
uses niacin
nicotinamide adenine dinucleotide (NAD)
uses riboflavin
flavin adenine dinucleotide (FAD)
Pyruvcate and lactate O-R reactions
Pyruvate is oxidized
lactate is reduced
glucose oxidization
results in CO2 and the reduction of oxygen to water
oxidizes (removes e-) food molecules to obtain energy (ATP)
cellular respiration
aerobic respiration of one glucose yields _____ ATP
30-32 (requires mitochondria)
anaerobic respiration of one glucose molecule yields ___ATP
2
where does glycolysis occur?
cytosol
what happens on glycolysis?
glucose (6C) is oxidized to form 2 molecules of pyruvate (3 C)
pyruvate is oxidized and joined with CoA to form acetyl-CoA
Synthesis of acetyl CoA/ transition reaction (occurs in mitochondria)
Acetyl CoA enters cycle producing NADH +H, FADH2, and ATP
Citric acid cycle (occurs in mitochondria)
NADH+H, FADH2 are oxidized to NAD and FAD to generate ATP
electron transport systems
Glycolysis consumes:
glucose
2 NAD+
2 ADP+2pi
glycolysis produces
2 pyruvate
2 ATP
H2O
2 NADH
Citric acid cycle consumes:
acetyl-CoA
3 NAD+
FAD
GDP
Citric acid cycle produces
2 CO2
1 ATP ( GTP)
3 NADH
FADH2
how many molecules of acetyl-CoA are produced from 1 glucose molecule?
2
oxidative phosphorylation uses oxygen
passage of e- along a series of e- carriers (how energy is derived from NADH FADH2) (major source of ATP)
how many carbons in acetyl CoA? pyruvate?
2, 3
occurs in cells with no mitochondria (red blood cells) or when there is no/low oxygen
Anaerobic Metabolism
What is pyruvate converted to in anaerobic metabolism?
lactate
how many ATP are form from every glucose molecule in anaerobic metabolism?
2
what is the livers role in anaerobic respiration?
- takes up lactate
- synthesizes compounds used (like glucose) from lactate
lipolysis
triglycerides broken down into fatty acids and glycerol
where does fatty acid oxidation take place?
mitochondria
what does fatty acid oxidization yield?
acetyl-CoA
what is produced from amino acids in FAO?
carnitine
C16 (palmitate) yields _____ acetyl-CoA molecules
8
each cycle in FAO results in fatty acid becoming:
shorter
FAO produces:
- acetyl-CoA
- NADH
- FADH2
ketone bodies are form from:
incomplete fatty acid oxidization
overflow of acetyl-CoA when its produced from FAO exceeds CAC demand:
ketogenesis
Protein Metabolism (anabolic or catabolic?)
catabolic
input of PM
vitamin B6
output of PM
ammonia (NH3)
what happens to the NH3
converted to ammonia, and then urea and excrete d in urine
froms acetyl CoA which can be used in the CAC or to make ketone bodies?
ketogenic amino acid
forms pyruvate which can make glucose via oxaloacetate
glucogenic amino acid
forming glucose from glucogenic amino acids and other compounds
gluconeogenesis
How are fatty acids synthesized?
formed from excess energy (carbs) with the addition of acetyl-CoA
major site of alcohol metabolism
liver
acetyaldehyde is converted to _____ in alcohol metabolism
acetyl CoA
Fasting encourages:
glycogen breakdown
fat breakdown
gluconeogenesis
synthesis of ketone bodies
feasting encourages:
glycogen synthesis fat synthesis protein synthesis urea synthesis insulin release
unable to metabolize phenylalanine
phenylketonuria
unable to metabolize galactose
galactosemia
inability to convert glycogen to glucose
glycogen storage disease