Chapter 8

Question 1

T cells are activated in the?

Answer 1

lymph node

Question 2

what happens at the site of infection

Answer 2

DC cells phagocytose microbes and present them on MHC class I and class II and travel through lymphatic vessels to secondary lymph organs

Question 3

what happens after DC and microbes travel through the lymphatic vessels?

Answer 3

DC enter and interact with T cells looking for a match and if there is a match it initiates adaptive immunity

Question 4

once adaptive immunity is initiated what happens

Answer 4

the DC is going to bind to the T cell and teach the T cell how to fight infection

Question 5

if the infection location is in the tissue and skin what secondary lymph organ does it go too

Answer 5

draining L.N

Question 6

if the infection location is in the blood what secondary lymph organ does it go too

Answer 6

spleen

Question 7

if the infection location is in the mucosa what secondary lymph organ does it go too

Answer 7

MALT

Question 8

steps after you step on a nail

Answer 8

2. DCs pick up microbes
3. DC travels to draining L.N
4. in the L.N DC interacts w/ T cells and activate other T cells

Question 9

receptor-mediated endocytosis of bacteria and microbes that replicate extracellular is what MHC class and T cell

Answer 9

Class II
CD4

Question 10

macropinocytosis of bacteria or viruses and extracellular infection is what MHC class and T cell

Answer 10

Class II
CD4

Question 11

viral infection or infection of DC by virus is what MHC class and T cell

Answer 11

Class I
CD8

Question 12

cross-presentation or no infection virus endocytosed of exogenous viral antigens is what MHC class and T cell

Answer 12

Class I
CD8

Question 13

T cell recirculate between the

Answer 13

blood and lymph

Question 14

when T cell recirculate between the blood and lymph the T cell enters via? and interact with DC via?

Answer 14

enter via HEV
interact with DC via MHC

Question 15

once the T cell enters via HEV and interacts with the DC via MHC what two things could it do?

Answer 15

A. recognize Ag and stay
B. not recognize Ag and leave via efferent lymph vessel

Question 16

what is extravasation?

Answer 16

T cells leaving the blood stream

Question 17

how do T cells cross HEV to get into the lymph node

Answer 17

1. there is loose adhesion
2. there are chemokine signals and increase the strong adhesion molecules
3. this tightly bind to endothelial cells
4. diapedesis making the it squeeze between endothelial cells

Question 18

T cell : L- selectin
name HEV
name DC
if both or one

Answer 18

HEV: SL^x+ CD34/ glycam
DC: none

Question 19

T cell: LFA-1
name HEV
name DC
if both or one

Answer 19

HEV: ICAM2
DC: none

Question 20

T cell: ICAM3
name HEV
name DC
if both or one

Answer 20

HEV: none
DC: LFA-1 or DC-Sign

Question 21

T cell: CD2
name HEV
name DC
if both or one

Answer 21

HEV: none
DC: LFA3

Question 22

L- selectin, LFA-1, ICAM3, and CD2 are what type of molecules

Answer 22

adhesion

Question 23

Naive cells are before or after encounter Ag

Answer 23

before encountering Ag

Question 24

activated cells are before or after encountering Ag

Answer 24

after encountering Ag

Question 25

how do cells keep recirculating?

Answer 25

through the S1P gradient

Question 26

what is the S1P gradient?

Answer 26

lipids on cells in L.N with a higher concentration on cells that are closer to the efferent lymphatic vessel

Question 27

when cells become activated what do they bind too?

Answer 27

bind to MHC and peptide on dendritic cell and gets signals to down regulate S1PR (CD19) on surface and upregulate adhesion to DCs

Question 28

DC=

Answer 28

teacher for the T cells

Question 29

T cells express S1PR which bind

Answer 29

S1P

Question 30

T cells need how many signals from DC for activation

Answer 30

2

Question 31

what is signal one for DC activation

Answer 31

TCR+ coreceptor interact with MHC

Question 32

what is signal two for DC activation

Answer 32

co-stimulation
CD28 (T cell) interacts with B7 (DC)

Question 33

what are two major T cell synapse components

Answer 33

adhesion and signaling

Question 34

p-SMAC is central or peripheral

Answer 34

peripheral

Question 35

c-SMAC is central or peripheral

Answer 35

central

Question 36

what two regions play a role in adhesion

Answer 36

p-smac and c-smac

Question 37

what plays a role in signaling

Answer 37

c-smac
TCR
costimulation

Question 38

is CD2 a adhesion molecule

Answer 38

yes

Question 39

what molecules are in c-smac

Answer 39

TCR
CD2
CD4
CD8
CD28
PKC-0

Question 40

what molecules are in p-smac

Answer 40

LFA-1
ICAM-1
talin