Chapter 7 Flashcards
A Membrane Structure and Function
Plasma Membrane
Functions: Protection and controlling what goes in and out.
“selective permeability”: transport proteins control what goes in and out. The phospholipid bilayer keeps out hydrophilic substances.
Phospholipid bilayer
A bunch of phospholipids with their hydrophobic tails facing each other.
Fluid Mosaic model
The plasma membrane is a fluid mosaic model because protein molecules bob in and out and flow around relatively freely. Proteins are not randomly distributed.
Evidence for fluid nature of cell membrane: Proteins and hybrid cells (two cells merging)
Fluidity
- Proteins and lipids can shift about sideways and the such
- Flip flop: lipids may flip-flop across the membrane
- Saturated hydrocarbon tails = less fluidity
- Cholesterol reduces membrane fluidity at moderate temperatures by reducing phospholipid movement, but at low temperatures it hinders solidification by being in the way.
Membrane Proteins
- Integral Proteins (carrier and channel): Includes transmembrane proteins. Penetrate the hydrophobic interior of the lipid bilayer. TransMemP span the membrane, other integral proteins extend only partway into the hydrophobic interior.
- Peripheral proteins: Found on both ‘faces’ of the plasma membrane. Are not embedded in the lipid bilayer at all; they are loosely bound to the surface of the membrane.
- ECM: Extracellular matrix. Attach to membrane proteins.
Membrane Protein Functions
- Transport
- Enzyme activity
- Signal Transduction
- Cell-cell Recognition
- Intercellular Joining
- Attachment to the cytoskeleton and extracellular matrix (ECM).
Cell recognition molecules
Carbohydrates, glycoproteins specifically. They serve as identification tags. Usually short-lived.
Passive transport
Doesn’t require energy
Diffusion
From high concentration to low concentration.
Osmosis
From low concentration to high concentration. Equalize out amount of water molecules/concentration.
Water Balance
Maintaining a balance of water. Hypertonic, Isotonic, and Hypotonic
Turgid
Firm. More water inside than normal.
Flaccid
The cell becomes limp, the plant wilts.
Plasmolysis
Causes the plant (protoplast)to wilt and can lead to plant death. As the plant cell shrivels, its plasma membrane pulls away from the cell wall at multiple places, this phenomenon is called plasmolysis.
Osmoregulation
Control of solute concentrations and water balance.
The maintenance of constant osmotic pressure in the fluids of an organism by the control of water and salt concentrations.
Facilitated Diffusions
Many polar molecules and ions blocked by the lipid bilayer of the membrane diffuse passively with the help of transport(channel) proteins that span the membrane.
Active Transport
Requires cellular energy. Usually pumps against its gradient.
Active vs. Passive Transport
Active always require cellular energy, passive transport does not.
Bulk Transport across Membrane
Large molecules such as proteins and p-saccharides, generally don’t cross the membrane by diffusion or transport proteins. Instead, they usually enter and leave the cell in bulk, packaged in vesicles.
Proton pump
The main electrogenic pump of plants, fungi and bacteria. Actively transports protons (H+) out of the cell. Requires ATP.
Cotransport: H+ and sugar
A transport protein (a cotransporter) can couple the “downhill” diffusion of the solute to the “uphill” transport of a second substance against its own concentration gradient.
Use ATP to get H+ out. Use cotransport to bring it back in with a glucose.
Exocytosis
Cell secretes certain molecules by the fusion of vesicles with the plasma membrane. An active transport
Endocytosis
The cell takes in molecules and particulate matter by forming new vesicles from the plasma membrane. Active transport. Bulk
Phagocytosis
Type of endocytosis. “Cellular eating.” A cell engulfs a particle by extending pseudopodia around it and packaging it within a membranous sac called a food vacuole.
Pinocytosis
Type of endocytosis. Gulps droplets of extracellular fluid into tiny vesicles, formed by infoldings of the plasma membrane.
Receptor-mediated endocytosis
A specialized type of pinocytosis that enables the cell to acquire bulk quantities of specific substances, even though those substances may not be very concentrated in the extracellular fluid(body fluid outside cell).
Hypertonic Solution
If a red blood cell is added to a hypertonic solution, there is more water outside the cell, causing water to rush in to the blood cell
Hypotonic Solution
If a red blood cell is added to a hypotonic solution, the water concentration will be less outside of the cell, causing water to rush out of the blood cell
Isotonic solution
:)
Lysis
Hypotonic solution outside of cell causes hemoLYSIS in a red blood cell
Crenation
Hypertonic solution outside of cell causes crenation in a red blood cell.
Water rushes into the cell.
Electrogenic pump
An ion pump that generates net flow of charge. An important example is the sodium-potassium exchange pump which transports two potassium ions into the cell for every three sodium ions transported out, a net outward current that makes the inside of the cell negative.
Contractile Vacuoles
A vacuole in some protozoans(Protists) which expels excess liquid on contraction.