Chapter 7 Flashcards
What is the plasma membrane
the boundary that separates the living cell from its surroundings.
Selective permeability
Allowing some substances to cross it more easily than others
What do cellular membranes have mosaics of?
Lipids and proteins
What are phospholipids
they are the most abundant lipid in the plasma membrane
A.) they are amphipathic molecules, containing hydrophobic and hydrophilic regions.
What does the fluid mosaic model say
It says that a membrane is a fluid structure with a mosaic of various proteins embedded in it
What are membranes made of
Membranes are made of proteins and lipids
Scientists studying the plasma membrane reasoned that it must be a _______
Phospholipid bilayer
In 1935, Hugh Davison and James Danielle proposed a _____ in which ____
Sandwhich model
It says that the phospholipid bilayer lies between two layers of globular proteins.
What are the two regions of the placement of membrane proteins?
Hydrophilic and Hydrophobic
In 1972, S. J. Singer and G. Nicholson proposed that _______
The membrane is a mosaic of proteins dispersed within the bilayer, with only the hydrophilic regions exposed to water.
What is freeze-fracture?
A preparation technique that splits a membrane along the middle of the phospholipid bilayer
Phospholipids in the plasma membrane can move within the ____
Bilayer
Lipids and some proteins drift___
Laterally
What happens to membranes as temperatures cool?
They switch form a fluid state to a solid state
The temperature at which a membrane solidifies depends on _____
The types of lipids
Which membranes are more fluid?
Membranes that are rich in unsaturated fatty acids are more fluid than those rich in saturated fatty acids.
What is an example for how fluid membranes are?
salad oil
How does cholesterol effect membrane fluidity in different temperatures?
At warm temps, cholesterol restrains movement of phospholipids
At cool temperatures, it maintains fluidity by preventing tight packing
How has ability to change the lipid compositions in response to temperature changes evolved?
It has evolved in organisms that live where temperatures vary
Peripheral proteins
These are bound to the surface of the membrane
Integral proteins
Penetrate the hydrophobic core
Transmembrane proteins
These are integral proteins that span the membrane.
What do the hydrophobic regions of an integral protein consist of?
One ore more stretches of non polar amino acids, usually coiled into alpha helices.
Six major functions of membrane proteins
- transport
- enzymatic activity
- signal transduction
- cell-cell recognition
- intercellular joining
- attachment to the cytoskeleton and extra cellular matrix
How do cells recognize each other
By binding to surface molecules that often contain carbohydrates on the extra cellular surface of the plasma membrane
What do membrane carbohydrates covalently bonded to lipids form?
Glycolipids
What do membrane carbohydrates covalently bonded to proteins form?
Glycoproteins