Chapter 11 - Section 2 Flashcards
Reception
A signaling molecule binds to a receptor protein, causing it change shape
What is often the initial transduction of the signal
A shape change
Most signal receptors are ____
Plasma membrane proteins
Where do water-soluble signal molecules bind?
They bind to specific sites on receptor proteins that span the plasma membrane
What are the three main types of membrane receptors?
1.) G protein-coupled receptors
2.) receptor tyrosine kinases
3.) ion channel receptors
G protein-coupled receptors
The largest family of cell surface receptors —-
Hetero trimeric G protein and a, b, and y.
If gdp is bound to the G protein, the G protein is________
Inactive
Receptor Tyrosine kinases
Membrane receptors that attach phosphate to tyrosines
T or F - a receptor tyrosine kinase can trigger multiple signal transduction pathways at once.
True
Many types of cancers are associated with ____
Abnormal functioning of receptor tyrosine kinases.
Ligand-gated ion channel
This receptor acts as a gate when the receptor changes shape
What ions does the ligand-gated ion channel allow
Na+ or Ca2+
Where are intracellular receptor proteins found?
they are found in the cytosol or nucleus of target cells
Which chemical messengers can readily cross the membrane and activate receptors
Small or hydrophobic chemical messengers.
