Chapter 68 - Sjögren Syndrome

Question 1

TABLE 68-4
Proposed Classification Criteria for Sjögren Syndrome

The classification of SS, which applies to individuals with signs/ symptoms that may be suggestive of SS, will be met in patients who have at least 2 of the following 3 objective features:
1. Positive serum _____ and/or _____ or (positive _____ and ANA titer ≥_____)

Answer 1

1. Positive serum anti-SSA/Ro and/or anti-SSB/La or (positive rheumatoid factor and ANA titer ≥1:320)

Question 2

TABLE 68-4
Proposed Classification Criteria for Sjögren Syndrome

The classification of SS, which applies to individuals with signs/ symptoms that may be suggestive of SS, will be met in patients who have at least 2 of the following 3 objective features:
2. Keratoconjunctivitis sicca with ocular staining score _____ (assuming that individual is not currently using daily eye drops for glaucoma and has not had corneal surgery or cosmetic eyelid surgery in the last _____ y)

Answer 2

2. Keratoconjunctivitis sicca with ocular staining score ≥3 (assuming that individual is not currently using daily eye drops for glaucoma and has not had corneal surgery or cosmetic eyelid surgery in the last 5 y)

Question 3

TABLE 68-4
Proposed Classification Criteria for Sjögren Syndrome

The classification of SS, which applies to individuals with signs/ symptoms that may be suggestive of SS, will be met in patients who have at least 2 of the following 3 objective features:
3. Labial salivary gland biopsy exhibiting focal lymphocytic sialadenitis with a focus score of _____ focus/4 mm2

Answer 3

3. Labial salivary gland biopsy exhibiting focal lymphocytic sialadenitis with a focus score of ≥1 focus/4 mm2

Question 4

TABLE 68-4
Proposed Classification Criteria for Sjögren Syndrome

Exclusion Criteria (7)

Answer 4

1. History of head and neck radiation treatment
2. Acquired immunodeficiency syndrome
3. Hepatitis C infection
4. Sarcoidosis
5. Amyloidosis
6. Graft-vs-host disease
7. IgG4-related disease