Chapter 61 - Lupus Erythematosus Flashcards
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Fixed erythema, flat or raised, over the malar eminences, tending to spare the nasolabial folds
Malar rash
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Erythematous raised patches with adherent keratotic scaling and follicular plugging; atrophic scarring may occur in older lesions
Discoid rash
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Skin rash as a result of unusual reaction to sunlight, by patient history or physician observation
Photosensitivity
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Oral or nasopharyngeal ulceration, usually painless, observed by a physician
Oral ulcers
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Nonerosive arthritis involving 2 or more peripheral joints, characterized by tenderness, swelling, or effusion
Arthritis
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Serositis (2)
Pleuritis
Pericarditis
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Convincing history of pleuritic pain or rub heard by a physician or evidence of pleural effusion
Pleuritis
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Documented by electrocardiogram or rub or evidence of pericardial effusion
Pericarditis
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Renal disorder (2)
Persistent proteinuria
Cellular casts
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Persistent proteinuria— ___ g/day or greater than ___ if quantitation not performed
Persistent proteinuria— >0.5 g/day or greater than 3+ if quantitation not performed
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
May be red cell, hemoglobin, granular, tubular, or mixed
Cellular casts
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Neurologic disorder (2)
Seizures
Psychosis
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Hematologic disorder (4)
Hemolytic anemia
Leukopenia
Lymphopenia
Thrombocytopenia
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Hemolytic anemia—with __________
Hemolytic anemia—with reticulocytosis
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Leukopenia— _____ μL total on ___ or more occasions
Leukopenia— <4000 μL total on 2 or more occasions
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Lymphopenia— _____/μL on ___ or more occasions
Lymphopenia— <1500/μL on 2 or more occasions
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Thrombocytopenia— _____ μL in the absence of offending drugs
Thrombocytopenia— <100,000 μL in the absence of offending drugs
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Immunologic disorder (3)
Anti-DNA
Anti–Smith antigen
Positive finding of antiphospholipid antibodies
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
Positive finding of antiphospholipid antibodies based on
(1) an abnormal serum level of __________,
(2) a _____ test result for _____ using a standard method, or
(3) a _____ serologic test for _____ known to be _____ for at least _____ and confirmed by __________ or fluorescent treponemal antibody absorption test __________
Positive finding of antiphospholipid antibodies based on
(1) an abnormal serum level of immunoglobulin G or immunoglobulin M anticardiolipin antibodies,
(2) a positive test result for lupus anticoagulant using a standard method, or
(3) a false-positive serologic test for syphilis known to be positive for at least 6 months and confirmed by Treponema pallidum immobilization or fluorescent treponemal antibody absorption test
TABLE 61-2
The 1982 Revised Criteria for Classification of Systemic Lupus Erythematosus
An abnormal titer of __________ by immunofluorescence of an equivalent assay at any point in time and in the absence of drugs known to be associated with “drug-induced lupus” syndrome
An abnormal titer of antinuclear antibody by immunofluorescence of an equivalent assay at any point in time and in the absence of drugs known to be associated with “drug-induced lupus” syndrome
TABLE 61-6
Therapeutic Options for Lupus Erythematosus–Specific Skin Disease
First line vs Second line vs Short course only vs Third line vs Worth considering
Topical glucocorticoids
First line
TABLE 61-6
Therapeutic Options for Lupus Erythematosus–Specific Skin Disease
First line vs Second line vs Short course only vs Third line vs Worth considering
Topical calcineurin inhibitor
First line
TABLE 61-6
Therapeutic Options for Lupus Erythematosus–Specific Skin Disease
First line vs Second line vs Short course only vs Third line vs Worth considering
Intralesional triamcinolone acetonide
TABLE 61-6
Therapeutic Options for Lupus Erythematosus–Specific Skin Disease
First line vs Second line vs Short course only vs Third line vs Worth considering
Hydroxychloroquine
Second line
