Chapter 36 - Sweet Syndrome

Question 1

TABLE 36-1
Diagnostic Criteria for Classical Sweet Syndrome versus Drug-Induced Sweet Syndrome

Classical vs Drug-Induced

Abrupt onset of painful erythematous plaques or nodules

Answer 1

Classical and Drug-Induced

Question 2

TABLE 36-1
Diagnostic Criteria for Classical Sweet Syndrome versus Drug-Induced Sweet Syndrome

Classical vs Drug-Induced

Histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis

Answer 2

Classical and Drug-Induced

Question 3

TABLE 36-1
Diagnostic Criteria for Classical Sweet Syndrome versus Drug-Induced Sweet Syndrome

Classical vs Drug-Induced

Pyrexia >38°C (100.4°F)

Answer 3

Classical and Drug-Induced

Question 4

TABLE 36-1
Diagnostic Criteria for Classical Sweet Syndrome versus Drug-Induced Sweet Syndrome

Classical vs Drug-Induced

Association with an underlying hematologic (most commonly acute myelogenous leukemia) or visceral malignancy (most commonly carcinomas of the genitourinary organs, breast, and gastrointestinal tract), inflammatory disease (Crohn disease and ulcerative colitis), or pregnancy, or preceded by an upper respiratory (streptococcosis) or gastrointestinal (salmonellosis and yersiniosis) infection or vaccination

Answer 4

Classical

Question 5

TABLE 36-1
Diagnostic Criteria for Classical Sweet Syndrome versus Drug-Induced Sweet Syndrome

Classical vs Drug-Induced

Excellent response to treatment with systemic corticosteroids or potassium iodide

Answer 5

Classical

Question 6

TABLE 36-1
Diagnostic Criteria for Classical Sweet Syndrome versus Drug-Induced Sweet Syndrome

Classical vs Drug-Induced

Abnormal laboratory values at presentation (3 of 4): erythrocyte sedimentation rate >20 mm/h; positive C reactive protein; >8000 μL leukocytes; >70% neutrophils

Answer 6

Classical

Question 7

TABLE 36-1
Diagnostic Criteria for Classical Sweet Syndrome versus Drug-Induced Sweet Syndrome

Classical vs Drug-Induced

Temporal relationship between drug ingestion and clinical presentation, or temporally related recurrence after oral challenge

Answer 7

Drug-Induced

Question 8

TABLE 36-1
Diagnostic Criteria for Classical Sweet Syndrome versus Drug-Induced Sweet Syndrome

Classical vs Drug-Induced

Temporally related resolution of lesions after drug withdrawal or treatment with systemic corticosteroids

Answer 8

Drug-Induced

Question 9

TABLE 36-10
Systemic Treatments for Sweet Syndrome

First vs Second Line

Prednisone

Answer 9

First

Question 10

TABLE 36-10
Systemic Treatments for Sweet Syndrome

First vs Second Line

Methylprednisolone sodium succinate

Answer 10

First

Question 11

TABLE 36-10
Systemic Treatments for Sweet Syndrome

First vs Second Line

Potassium iodide

Answer 11

First

Question 12

TABLE 36-10
Systemic Treatments for Sweet Syndrome

First vs Second Line

Colchicine

Answer 12

First

Question 13

TABLE 36-10
Systemic Treatments for Sweet Syndrome

First vs Second Line

Indomethacin

Answer 13

Second

Question 14

TABLE 36-10
Systemic Treatments for Sweet Syndrome

First vs Second Line

Clofazimine

Answer 14

Second

Question 15

TABLE 36-10
Systemic Treatments for Sweet Syndrome

First vs Second Line

Cyclosporine

Answer 15

Second

Question 16

TABLE 36-10
Systemic Treatments for Sweet Syndrome

First vs Second Line

Dapsone

Answer 16

Second