Chapter 53 - Paraneoplastic Pemphigus

Question 1

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

First line vs Second line

Prednisone

Answer 1

First line

Question 2

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

First line vs Second line

Rituximab

Answer 2

First line

Question 3

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

First line vs Second line

Daclizumab

Answer 3

First line

Question 4

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

First line vs Second line

Basiliximab

Answer 4

First line

Question 5

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

First line vs Second line

Cyclosporine

Answer 5

Second line

Question 6

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

First line vs Second line

Cyclophosphamide

Answer 6

Second line

Question 7

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

First line vs Second line

Mycophenolate mofetil

Answer 7

Second line

Question 8

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

First line vs Second line

High-dose IV immunoglobulin

Answer 8

Second line

Question 9

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

First line vs Second line

Plasmapheresis

Answer 9

Second line

Question 10

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

USUAL DOSE

Prednisone

Answer 10

0.5-1.0 mg/kg IV daily × 3 days

Question 11

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

USUAL DOSE

Rituximab

Answer 11

375 mg/m2 IV weekly × 4 wk, repeat every 6 months

Question 12

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

USUAL DOSE

Daclizumab

Answer 12

2 mg/kg IV weekly × 4 wk, then every other week indefinitely

Question 13

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

USUAL DOSE

Basiliximab

Answer 13

20 mg IV on day 0 and day 4, repeat every 3-4 months

Question 14

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

USUAL DOSE

Cyclosporine

Answer 14

5 mg/kg daily

Question 15

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

USUAL DOSE

Cyclophosphamide

Answer 15

2.5 mg/kg daily

Question 16

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

USUAL DOSE

Mycophenolate mofetil

Answer 16

1000 mg by mouth twice daily

Question 17

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

USUAL DOSE

High-dose IV immunoglobulin

Answer 17

2 g/kg IV, repeat every 3-4 wk

Question 18

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

USUAL DOSE

Plasmapheresis

Answer 18

Every other day for 6 total treatments

Question 19

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

OTHER DOSING

Prednisone

Answer 19

Methylprednisolone, 1000 mg

Question 20

TABLE 53-5
Treatments for Paraneoplastic Pemphigus

OTHER DOSING

Rituximab

Answer 20

1000 mg IV weekly × 2 wk