Chapter 6: Lipids and Membranes Flashcards

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1
Q

What is diffusion and how does it occur?

A

Movement of any molecule down its concentration gradient. It occurs spontaneously without any energy

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2
Q

What is turgor pressure and why is it important to plans?

A

The pressure produced by water coming into a cell due to a hypotonic solution. The cell is able to be rigid and retain water

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3
Q

How does facilitated diffusion work?

A

Channel proteins or carrier provide a doorway for certain polar molecules and ions to pass

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4
Q

How does LDL get increased?

A

A diet high in saturated fats

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5
Q

What does increased HDL lead to?

A

More cholesterol excretion

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6
Q

How many sodiums are moved out of the cell and how many potassiums move in the cell in the sodium-potassium pump?

A

3 sodiums move out and 2 potassiums move in

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7
Q

What type of protein is a GLUT-1 transporter?

A

Carrier protein

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8
Q

Why are saturated fats solid at room temperature?

A

They can pack close together due to their linear structure

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9
Q

Which fats are considered “healthy” fats?

A

Unsaturated fats

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10
Q

How does an unsaturated fat differ from a saturated fat?

A

Unsaturated fats have one or more double bonds between C; there is one fewer H on each double-bonded carbon

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11
Q

What is active transport?

A

When energy is required

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12
Q

What characterizes a steroid?

A

A carbon skeleton with four fused rings

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13
Q

What causes cystic fibrosis?

A

Mutant CFTR channels (channel proteins). Chloride on inside can’t fill in the holes on the channels and the channels won’t be open so mucus accumulates outside the cell

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14
Q

How do cotransporters work?

A

They use the power of ions moving down their gradient to move a molecule against its gradient

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15
Q

What molecules can easily cross the selectively permeable membrane?

A

Small nonpolar molecules like hydrocarbons, CO2, and O2

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16
Q

What happens at equilibrium?

A

The ions on both sides are balanced and there is no net movement, but the ions still continue to move across

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17
Q

What are peripheral proteins?

A

Membrane proteins that are loosely bound to the surface of the membrane and often interact with exposed surface of integral proteins

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18
Q

Why are unsaturated fats liquid at room temperature?

A

They can’t pack as close together due to their bendy structure

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19
Q

What is the key characteristic that all lipids share?

A

Hydrophobic

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20
Q

What do double bonds between C in unsaturated fats cause the fatty acid chain to do?

A

Kink and bend in a different direction

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21
Q

What does hypotonic mean?

A

Less solutes are in the environment

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22
Q

How does a glycerol bind with a fatty acid?

A

Dehydration

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23
Q

What are aquaporins?

A

Channel proteins that allow water to flow through at an extremely high rate

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24
Q

How specific are cotransporters?

A

Very specific. Both molecules must be present for it to work

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25
Q

What is HDL?

A

High density lipoprotein. Removes LDL from the bloodstream. “Good” cholesterol

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26
Q

How often does the plasma membrane move?

A

It moves laterally 10^7 times per second

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27
Q

What influences membrane permeability?

A

Fatty acids of different lengths and saturation

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28
Q

What does isotonic mean?

A

The environment outside the cell is the same as inside

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29
Q

What are essential fatty acids and how do we get them?

A

Fatty acids we must get through our diet because our bodies don’t produce them. Omega 3s, Omega 6, Fish oil, etc.

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30
Q

How is it determined what can pass through a channel protein?

A

What amino acids are expressed

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31
Q

How does soap work?

A

Soap dissolves in water and orients themselves w the oil/grease, agitation separates oil from surface, and it is washed away in running water. It takes advantage of hydrophilic and hydrophobic

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32
Q

Which fats are solid at room temperature and which are liquid at room temperature?

A

Saturated are solid and unsaturated are liquid

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33
Q

How does a saturated fat differ from an unsaturated fat?

A

Saturated fats have no double bonds between C and have the most H atoms as possible

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34
Q

Which fats clog arteries and why?

A

Saturated fats because they can pack close together

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35
Q

What are trans fats?

A

Mostly man-made fats that exist naturally in very small amounts. They are created by adding hydrogen atoms to unsaturated fats. They were an attempt to create healthy saturated fats

36
Q

Are lipids polymers?

A

No, they are clumped together because they are hydrophobic

37
Q

Do carrier proteins change shape?

A

Yes

38
Q

What happens if the environment is hypertonic to the cell?

A

Water moves out of the cell

39
Q

What is cystinuria?

A

Defect in carrier protein that transports cysteine across membrane of kidney cells leading to bladder stones. Very common in dogs

40
Q

What are the 3 ways molecules move across the membrane?

A

Diffusion, facilitated diffusion, and active transport

41
Q

What types of steroids are made from cholesterol?

A

Sex hormones (estrogen and testosterone)

42
Q

What molecules require a membrane protein to cross the selectively permeable membrane?

A

Ions and polar molecules

43
Q

Do channel proteins change shape?

A

No

44
Q

What does hypertonic mean?

A

More solutes are in the environment

45
Q

What are the functions of membrane proteins?

A

Transport, enzyme activity, signal transduction, cell-cell recognition, intercellular joining, attachment to the cytoskeleton and extracellular matrix (ECM)

46
Q

Is it easy for the membrane to flip-flop?

A

No, it is very rare

47
Q

What are fats more commonly known as?

A

Triglycerides

48
Q

What are the three types of lipids that are the most biologically relevant?

A

Steroids, fats, and phospholipids

49
Q

What are integral (transmembrane) proteins?

A

Membrane proteins that span the membrane with segments both inside and outside the cell

50
Q

How do longer hydrocarbon chains effect membrane permeability?

A

They decrease permeability because molecules have to travel further when the chains are longer

51
Q

What is the difference between HDL and LDL?

A

HDL removes LDL that clumps in the bloodstream. The difference lies in what other proteins are present

52
Q

What does cholesterol do?

A

It is a precursor from which other steroids are synthesized. It is also an important component of the cell membrane

53
Q

What can happen with a mutation to the aquaporin-2 gene?

A

Nephrogenic diabetes insipidus. Can’t absorb water the way they’re supposed to and have to always have water with them

54
Q

What does secondary active transport (cotransport) do?

A

Uses the gradient created by an ATP powered pump to power the transport of a molecule against its gradient

55
Q

What proteins are used in facilitated diffusion?

A

Channel proteins and carrier proteins

56
Q

What type of transport is facilitated diffusion?

A

Passive transport

57
Q

How do proteins arrange themselves in the membrane?

A

Hydrophilic parts are on the outside and the hydrophobic parts and in between the bilayer

58
Q

What do all different types of cells contain?

A

Different membrane proteins

59
Q

When are ion pumps used?

A

Active transport

60
Q

What do HDL and LDL stand for?

A

High density lipoprotein and low density lipoprotein

61
Q

What does the word hydrogenated indicate?

A

Trans fats

62
Q

What is osmosis?

A

The diffusion of water across a semipermeable membrane

63
Q

How do viruses infect certain cells?

A

They need certain receptors to bind to

64
Q

What happens during active transport?

A

Energy (ATP) is used to move molecules against their concentration gradient

65
Q

Why do we use trans fats?

A

They were designed as a healthy alternative to saturated fats, but they turned out to be worse for us than saturated fats

66
Q

What types of molecules use facilitated diffusion?

A

Polar molecules and ions

67
Q

What does amphipathic mean? What molecule is amphipathic?

A

It has two different regions with distinct properties (hydrophilic and hydrophobic). Phospholipids are amphipathic

68
Q

How are trans fats made?

A

Taking an unsaturated fat and getting rid of the C double bonds or changing the configuration to end with an unsaturated fat with the properties of a saturated fat

69
Q

What are the two parts of a phospholipid?

A

Hydrophilic phosphate head and hydrophobic fatty acid tails

70
Q

Do membranes have the same mosaic everywhere?

A

No, it is different everywhere

71
Q

How do phospholipids orient themselves in a membrane?

A

The tails face in and the heads face out

72
Q

What do ion pumps do?

A

Maintain electrochemical gradients and membrane potentials for nerve impulses

73
Q

Why are phospholipids able to form membranes rapidly?

A

Because they are amphipathic

74
Q

What does the fluid mosaic model imply?

A

The membrane is always moving and made up of more than just phospholipids

75
Q

What happens if the environment is hypotonic to the cell?

A

Water moves into the cell

76
Q

What is LDL?

A

Low density lipoprotein. It clogs arteries. “Bad” cholesterol

77
Q

What are the two molecules that fats are made from?

A

Glycerol and fatty acid

78
Q

What type of lipid is cholesterol?

A

Steroid

79
Q

Is energy used on a cotransporter?

A

No, it is used to create a build up of charge on one side.

80
Q

How do carrier proteins work?

A

Change shape to shuttle molecules across the membrane. They are a doorway with a door. The molecule comes in and the door to the extracellular fluid closes as the one to the interior opens

81
Q

How do you distinguish between steroids?

A

Different chemical groups are attached to the four carbon rings

82
Q

What are the two major types of membrane proteins?

A

Integral (transmembrane) and peripheral

83
Q

What is passive transport?

A

When no energy is required

84
Q

These macromolecules don’t mix with water

A

Lipids

85
Q

Are fats polymers?

A

No

86
Q

How do molecules move down their concentration gradients?

A

From high to low concentration without being effected by other substances