Chapter 6: 6.14 Eukaryotic Translational/Post-Translational Regulation

Question 1

What is translational regulation?

Answer 1

It includes controlling how well the translational machinery is able to bind to the mRNA by phosphorylation of certain proteins

Question 2

What is post-translational regulation?

Answer 2

Largely involves chemical modification of translated proteins that can impact how well they work and how long they remain in the cell

Question 3

What are examples of post-translational regulation?

Answer 3

• Methylation
• Acetylation
• Phosphorylation
• Ubiquitination
• etc.

Question 4

Define:

Ubiquitination

Answer 4

The addition of ubiquitin
* Tags the protein for degradation by the proteasome
* A post-translational regulation

Question 5

Describe:

Proteasome

Answer 5

A large protein complex chaped like a barrel
* Degrades proteins to regulate the level of proteins in the cell

Question 6

A protein destined for degradation will have…

Answer 6

Ubiquitin/Degron signal attached to it

Question 7

Define:

Recognin

Answer 7

A chaperone that recognizes the degron signal and brings the protein to the proteasome to be broken down and recycled