Chapter 55: Breast- LCIS

Question 1

What is LCIS?

Answer 1

Lobular Carcinoma In Situ

Question 2

What are the signs/symptoms?

Answer 2

There are none

Question 3

What are the mammographic findings?

Answer 3

There are none

Question 4

How is the diagnosis made?

Answer 4

LCIS is found incidentally on biopsy

Question 5

What is the major risk?

Answer 5

Carcinoma of either breast

Question 6

What percentage of women with LCIS develop an invasive breast carcinoma?

Answer 6

≈30% in the 20 years after diagnosis of LCIS!

Question 7

What type of invasive breast cancer do patients with LCIS develop?

Answer 7

Most commonly, infiltrating ductal carcinoma, with equal distribution in the contralateral and ipsilateral breasts

Question 8

What medication may lower the risk of developing breast cancer in LCIS?

Answer 8

Tamoxifen for 5 years will lower the risk up to 50%, but with an increased risk of endometrial cancer and clots; it must be an individual patient determination

Question 9

What is the treatment of LCIS?

Answer 9

Close follow-up (or bilateral simple mastectomy in high-risk patients)