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251 Final > Chapter 54 > Flashcards

Chapter 54 Flashcards

1
Q

What do biological response modifying drugs do?

A

Alter the body’s response to disease

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2
Q

What are the 2 categories of biological response modifying drugs

A

Hematopoietic
Immunomodulating

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3
Q

What are the 4 types of immunomodulating drugs

A

Interferons
Monoclonal antibodies
Interleukin receptor agonists and antagonists
Miscellaneous

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4
Q

Biological response modifying drugs either enhance or _ the immune system

A

Restrict

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5
Q

What do immunomodulating drugs do

A

Therapeutically alter the immune response to malignant cancer cells

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6
Q

Immunomodulating drugs are part of cancer therapy along with what other three things

A

Surgery
Chemo
Radiation

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7
Q

What other than cancer can Immunomodulating drugs be used for

A

Autoimmune disease
Inflammatory disease
Infectious disease

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8
Q

What is the mechanism of action of biological response modifying drugs (3)

A

1-enhance hematopoietic function
2-enhance or regulate immune defence against tumour
3-Precent cancer from spreading (stops cell growth)

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9
Q

What are the two components of the immune system

A

Humoral
Cell mediated

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10
Q

Humoral immunity is the

A

B cells (antibodies)

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11
Q

Cell mediated immunity is the

A

T cells

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12
Q

Where do B cells originate from

A

Bone marrow

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13
Q

What type of cell is known as the memory cell

A

B cell

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14
Q

What is another word for immunoglobulin

A

Antibody

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15
Q

What are MONOclonal antibodies

A

Identical cells derived from a single cell

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16
Q

Where do T cells originate?
Where do they mature?

A

Bone marrow
Thymus

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17
Q

What do cytotoxic T cells do

A

Directly kill targets by causing cell lysis

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18
Q

What do T helper cells do

A

Direct many other components of the immune system

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19
Q

What do T suppressor cells do

A

Limit and control the immune response

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20
Q

A healthy immune system has what ratio of t helper cells to t suppressor cells

A

Double helper cells compared to suppressor

21
Q

What is a complication of having too many T suppressor cells

A

Cancer cells go unnoticed

22
Q

Hematopoietic drugs are produced by what kind of technology

A

DNA

23
Q

Hematopoietic drugs do what

A

Promote synthesis of major blood components

24
Q

What type of drug enables higher doses of chemo to be given

A

Hematopoietic

25
Q

Mechanism of action for hematopoietic drugs

A

Decrease anemia, neutropenia, and thrombocytopenia from chemo

26
Q

What is neutropenia

A

When neutrophils are low

27
Q

When is reverse isolation necessary

A

When the patient has low WBC and is not going to be able to fight off infection if they get sick

28
Q

What kinds of patients would receive hematopoietic drugs

A

Patients with bone marrow destruction from chemo

29
Q

How to hematopoietic drugs impact the overall immune system

A

Enhance functions of mature immune cells to kill cancer, virus, fungus cells

30
Q

Interferons are proteins with what 3 properties

A

Antiviral
Antitumour
Immunomodulating

31
Q

Interferons are identical to what other cell in the body that are naturally present

A

Interferon cytokines

32
Q

Do interferons enhance or suppress immune system cells

A

Enhance

33
Q

What autoimmune disorder would interferons be used as an immune suppressor

A

MS

34
Q

What type of Immunomodulating targets cancer cells and has a minimal effect on healthy cells

A

Monoclonal antibodies

35
Q

What type of immunomodulator has few adverse effects compared to cancer drugs

A

Monoclonal antibodies

36
Q

Monoclonal antibodies are contraindicated in those with active TB and other infections why?

A

It suppresses the immune system so if someone has and infection it could kill them if they start taking this

37
Q

What kinds of side effects do people get from monoclonal antibodies

A

Flu-like

38
Q

Monoclonal antibodies are Anti-TNF what does this mean

A

TNF is a cytokine that causes inflammation. The med stops inflammation.

39
Q

Interleukins are a natural part of the immune system what are they classified as

A

Lymphokines

40
Q

What type of immunomodulator recognizes and destroys only cancer cells and not healthy cells

A

Interleukins

41
Q

What is rheumatoid arthritis

A

Autoimmune disorder: inflammation and tissue damage in joints

42
Q

What are the 2 treatments given for rheumatoid arthritis

A

NSAIDS, disease modifying anti rheumatic drugs (DMARD)

43
Q

Is there a cure for rheumatic arthritis

A

No

44
Q

How is osteoarthritis different from rheumatoid arthritis

A

Not an autoimmune disease. Happens with age

45
Q

What do disease modifying anti rheumatic drugs so

A

Anti inflammatory. Have Immunomodulating effects. Suppress immune system

46
Q

DMARDS are contraindicated for

A

Current infections

47
Q

How long does it take DMARDS to work

A

Several weeks

48
Q

Should non-biologics or biologics be used first to treat RA

A

Non-biologics

49
Q

If someone is taking biological response modifiers what condition needs urgent treatment

A

Febrile and neutropenia

251 Final (13 decks)

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