Chapter 54

Question 1

What do biological response modifying drugs do?

Answer 1

Alter the body’s response to disease

Question 2

What are the 2 categories of biological response modifying drugs

Answer 2

Hematopoietic
Immunomodulating

Question 3

What are the 4 types of immunomodulating drugs

Answer 3

Interferons
Monoclonal antibodies
Interleukin receptor agonists and antagonists
Miscellaneous

Question 4

Biological response modifying drugs either enhance or _ the immune system

Answer 4

Restrict

Question 5

What do immunomodulating drugs do

Answer 5

Therapeutically alter the immune response to malignant cancer cells

Question 6

Immunomodulating drugs are part of cancer therapy along with what other three things

Answer 6

Surgery
Chemo
Radiation

Question 7

What other than cancer can Immunomodulating drugs be used for

Answer 7

Autoimmune disease
Inflammatory disease
Infectious disease

Question 8

What is the mechanism of action of biological response modifying drugs (3)

Answer 8

1-enhance hematopoietic function
2-enhance or regulate immune defence against tumour
3-Precent cancer from spreading (stops cell growth)

Question 9

What are the two components of the immune system

Answer 9

Humoral
Cell mediated

Question 10

Humoral immunity is the

Answer 10

B cells (antibodies)

Question 11

Cell mediated immunity is the

Answer 11

T cells

Question 12

Where do B cells originate from

Answer 12

Bone marrow

Question 13

What type of cell is known as the memory cell

Answer 13

B cell

Question 14

What is another word for immunoglobulin

Answer 14

Antibody

Question 15

What are MONOclonal antibodies

Answer 15

Identical cells derived from a single cell

Question 16

Where do T cells originate?
Where do they mature?

Answer 16

Bone marrow
Thymus

Question 17

What do cytotoxic T cells do

Answer 17

Directly kill targets by causing cell lysis

Question 18

What do T helper cells do

Answer 18

Direct many other components of the immune system

Question 19

What do T suppressor cells do

Answer 19

Limit and control the immune response

Question 20

A healthy immune system has what ratio of t helper cells to t suppressor cells

Answer 20

Double helper cells compared to suppressor

Question 21

What is a complication of having too many T suppressor cells

Answer 21

Cancer cells go unnoticed

Question 22

Hematopoietic drugs are produced by what kind of technology

Answer 22

DNA

Question 23

Hematopoietic drugs do what

Answer 23

Promote synthesis of major blood components

Question 24

What type of drug enables higher doses of chemo to be given

Answer 24

Hematopoietic

Question 25

Mechanism of action for hematopoietic drugs

Answer 25

Decrease anemia, neutropenia, and thrombocytopenia from chemo

Question 26

What is neutropenia

Answer 26

When neutrophils are low

Question 27

When is reverse isolation necessary

Answer 27

When the patient has low WBC and is not going to be able to fight off infection if they get sick

Question 28

What kinds of patients would receive hematopoietic drugs

Answer 28

Patients with bone marrow destruction from chemo

Question 29

How to hematopoietic drugs impact the overall immune system

Answer 29

Enhance functions of mature immune cells to kill cancer, virus, fungus cells

Question 30

Interferons are proteins with what 3 properties

Answer 30

Antiviral Antitumour Immunomodulating

Question 31

Interferons are identical to what other cell in the body that are naturally present

Answer 31

Interferon cytokines

Question 32

Do interferons enhance or suppress immune system cells

Answer 32

Enhance

Question 33

What autoimmune disorder would interferons be used as an immune suppressor

Answer 33

MS

Question 34

What type of Immunomodulating targets cancer cells and has a minimal effect on healthy cells

Answer 34

Monoclonal antibodies

Question 35

What type of immunomodulator has few adverse effects compared to cancer drugs

Answer 35

Monoclonal antibodies

Question 36

Monoclonal antibodies are contraindicated in those with active TB and other infections why?

Answer 36

It suppresses the immune system so if someone has and infection it could kill them if they start taking this

Question 37

What kinds of side effects do people get from monoclonal antibodies

Answer 37

Flu-like

Question 38

Monoclonal antibodies are Anti-TNF what does this mean

Answer 38

TNF is a cytokine that causes inflammation. The med stops inflammation.

Question 39

Interleukins are a natural part of the immune system what are they classified as

Answer 39

Lymphokines

Question 40

What type of immunomodulator recognizes and destroys only cancer cells and not healthy cells

Answer 40

Interleukins

Question 41

What is rheumatoid arthritis

Answer 41

Autoimmune disorder: inflammation and tissue damage in joints

Question 42

What are the 2 treatments given for rheumatoid arthritis

Answer 42

NSAIDS, disease modifying anti rheumatic drugs (DMARD)

Question 43

Is there a cure for rheumatic arthritis

Answer 43

No

Question 44

How is osteoarthritis different from rheumatoid arthritis

Answer 44

Not an autoimmune disease. Happens with age

Question 45

What do disease modifying anti rheumatic drugs so

Answer 45

Anti inflammatory. Have Immunomodulating effects. Suppress immune system

Question 46

DMARDS are contraindicated for

Answer 46

Current infections

Question 47

How long does it take DMARDS to work

Answer 47

Several weeks

Question 48

Should non-biologics or biologics be used first to treat RA

Answer 48

Non-biologics

Question 49

If someone is taking biological response modifiers what condition needs urgent treatment

Answer 49

Febrile and neutropenia