Chapter 5: Histology Flashcards
how many cells are in the human body?
50 trillion
how many cell types are in the human body?
200
what are the four broad categories of tissues?
- epithelial tissue
- connective tissue
- nervous tissue
- muscular tissue
structure with discrete boundaries that is composed of two or more tissue types
organ
study of tissues and how they are arranged into organs
histology
group of similar cells and cell products working together to perform a specific role in an organ
tissue
4 primary tissues differ from each other in
types and functions of cells, characteristics of the matrix (extracellular material), relative amount of space occupied by cells vs. matrix
matrix composed of
fibers, clear gel called ground substances (aka tissue fluid extracellular fluid (ECF), interstitial fluid, tissue gel
how many germ layers do embryonic tissues have?
3
what gives rise to epidermis and nervous system?
ectoderm (outer)
what gives rise to mucous membrane lining digestive and respiratory tracts, digestive glands, among other things?
endoderm (inner)
what becomes gelatinous tissue called mesenchyme?
mesoderm
wispy collagen fibers and fibroblasts in gel matrix; gives rise to cardiac muscle, bone, blood
mesenchyme
what do histologists use to prevent decay and preserve tissue sections?
fixative
tissue cut on its long axis
longitudinal section
tissue cut perpendicular to long axis of organ
cross section/ transverse section
tissue cut at angle between cross and longitudinal sections
oblique
tissue is rubbed across a slide (i.e blood; liquid tissue)
smear
some membranes and cobwebby tissues are laid out on a slide (ex. areolar tissue; soft tissue)
spread
sheets of closely adhering cells; one or more cells thick; cover body surfaces and line body cavities; upper surface usually exposed to the environment or an internal space in the body; constitutes most glands
epithelia
what is the function of epithelial tissue?
protect, produce and release secretions, excrete waste, absorb, filter substances, sense stimuli
what are the 5 distinguishing characteristics of epithelial tissue?
- polarity, 2. specialized contacts, 3. supported by connective tissues, 4. avascular, but innervated, 5. regeneration
what are the two sides of epithelial tissue?
apical surface and basal surface
what does the apical surface face?
upper free side; top; outwards towards surface or cavity
what does the basal surface face?
attached side; bottom; inwards towards body
tight junctions and desmosomes are both?
lateral contacts
does epithelial tissue contain blood vessels?
no
does epithelial tissue contain nerves?
yes
multiple layers of cells ____________
stratified
one layer of cells
simple
flat cells__________
squamous
cube cells_________
cuboidal
cells taller than they are wide_______________
columnar
most diverse and most abundant type of tissue
connective
what are the functions of connective tissue?
supports, connects, and protects organs; binding of organs, physical protection, immune protection, movement, storage, heat production, transport
4 main classes of connective tissues
connective tissue proper, cartilage, bone, blood
all connective tissues have 3 main elements___________________
ground substance, fibers, cells
what makes up the extracellular matrix?
ground substance and fibers
unstructured gel like material that fills space between cells
ground substance
what does ground substance consist of?
glycosaminoglycans (GAGs), long polysaccharides composed of amino sugars, uronic acid, chondroitin sulfate, proteoglycans, adhesive glycoproteins
what are the 3 types of fibers of fibrous connective tissue?
collagenous fibers, reticular fibers, elastic fibers
most abundant of the body’s proteins, tough flexible and stretch resistant, tendons, ligaments and deep layer of the skin are mostly this
collageneous fibers
thin, highly branched collagen fibers coated with glycoprotein, form framework of spleen and lymph nodes
reticular fibers
thinner than collagenous fibers, made of protein called elastin; allows stretch and recoil
elastic fibers
immature form of cell that actively secretes ground substance and ECM fibers
blast cells
mature, less active form of cell that now becomes part of and help maintain health of matrix
cyte cells
where are fibroblasts?
connective tissue proper
where are chondroblasts found?
cartilage
where are osteoblasts found?
bone
where are hematopoietic stem cells found?
bone marrow
phagocytize foreign material and activate immune system when they sense foreign matter
macrophages
white blood cells
leukocytes
white blood cells that attack bacteria
neutrophils
white blood cells that react against bacteria toxins, and other foreign agents
lymphocytes
synthesize antibodies
plasma cells
cells often found alongside blood vessels; secrete heparin to inhibit clotting; secrete histamine to dilate blood vessels
mast cells
what does heparin do?
inhibit clotting
what does histamine do?
dilate blood vessels
___________store triglycerides
adipocytes
tissue specialized for communication by electrical and chemical signals; regulates and controls body functions
nervous tissue
what two specialized cells is nervous tissue made of?
neurons and neuroglia
what kind of cells detect stimuli and transmit coded info rapidly to other cells? (nerve cells)
neurons
what kind of cells protect, insulate and support neurons, and are more numerous than neurons?
neuroglia (glial cells)
what kind of tissue is composed of cells that are specialized to contract in response to stimulation? (primary job is to exert physical force; creates movement involved in body and limb movement, digestion, waste elimination, breathing, speech, and blood circulation; important source of body heat)
muscular tissue
what are the 3 types of muscle tissue?
skeletal muscle tissue, cardiac muscle tissue, smooth muscle tissue
found in skeletal muscle; voluntary
skeletal muscle tissue
found in walls of heart; involuntary
cardiac muscle tissue
mainly in walls of hollow organs other than heart; involuntary
smooth muscle tissue
connections between two cells
cell junctions
where are cells anchored?
to each other or their matrix
linkage between two adjacent cells by transmembrane cell adhesion proteins; located near apical pole in epithelia; seals off intercellular space, making it difficult for a substance to pass between cells
tight junctions
patches that hold cells together (like clothing snap) keeps cells from pulling apart- resist mechanical stress
desmosome
anchor basal cells of an epithelium to underlying basement membrane
hemidesmosome (half desmosome)
formed by ring like connexons; ions nutrients and other small solutes pass between cells; located in cardiac and smooth muscle, embryonic tissue
gap (communicating) junctions
cell/organ that secretes substances for use elsewhere in body or releases them for elimination from body (usually composed of epithelial tissue in a connective tissue framework and capsule
gland
product useful to body
secretion
waste product
excretion
maintain their contact with surface by way of duct (kind of gland)
exocrine gland (ex of surface: sweat tear/ pancreas, salivary gland
no ducts; secrete hormones directly into blood (kind of gland)
endocrine gland
chemical messengers that stimulate cells elsewhere in the body
hormones
found in an epithelium that is predominantly nonsecretory (can be exocrine or endocrine)
unicellular glands
connective tissue covering of an exocrine gland
capsule
connective tissue framework of the gland; supports and organizes the glandular tissue
stroma
consists of cells that perform the tasks of synthesis and secretion; typically cuboidal or simple columnar epithelium
parenchyma
duct shape (unbranched)
simple
duct shape (branched)
compound
gland shape: narrow secretory portion
tubular
gland shape: secretory cells form dilated sac (acinus or alveolus)
acinar
gland shape: both tubular and acinar portions
tubloacinar
type of secretion: produce thin, watery secretions; perspiration, milk, tears, digestive juices
serious glands
type of secretion: produce glycoprotein, mucin, which absorbs water to form mucus
mucous glands
unicellular mucous glands
goblet cells
type of secretion: contain both serous and mucous cell types and produce a mixture of the two types of secretions
mixed glands
types of secretions: release whole cells (sperm and egg cells)
cytogenic glands
what are the 3 modes of secretion
merocrine, apocrine, and holocrine
mode of secretion that uses vesicles that release their secretion by exocytosis ex. tear glands, pancreas, gastric glands
merocrine secretion
mode of secretion: a lipid droplet covered by membrane and cytoplasm buds from cell surface
apocrine secretion
mode of secretion: cells accumulate a product until they disintegrate ex. oil glands of scalp skin and eyelids
holocrine secretion
what kind of tissues can membranes be?
membranes can be only epithelial, only connective or a mix of epithelial, connective and muscular tissues?
what are 3 major types of membranes?
cutaneous membranes, mucous membranes, serious membranes
largest membrane in body; composed of stratified squamous epithelium resting on a layer of dermis function is protection
cutaneous membrane (skin)
this membrane lines passages that open to the external environment (i.e digestive tract)
mucous membrane
internal membranes that are closed to the exterior; simple suqamous epithelium resting on a layer of areolar tissue
serous membrane
growth through cell multiplication
hyperplasia
enlargement of preexisting cells
hypertrophy
development of a tumor; benign or malignant; composed of abnormal; nonfunctional tissue
neoplasia
development of a more specialized form and function by unspecialized tissue
differentiation
changing from one type of mature tissue to another
metaplasia
undifferentiated cells that are not yet performing any specialized function
stem cells
ability of a stem cell to give rise to a diversity of mature cell types
developmental plasticity
stem cells that have potential to develop into any type of fully differentiated human cell including accessory organs of pregnancy (from cells of very early embryo)
totipotent embryonic stem cell
stem cells that can develop into any type of cell in the embryo but not accessory organs of pregnancy (from cells of inner cell mass of embryo : blastocyst)
pluripotent embryonic stem cell
undifferentiated cells found in mature organs
adult stem cell
adult stem cell able to develop into two or more cell line (i.e bone marrow stem cell)
multipotent
adult stem cell only able to produce one kind of cell tyoe
unipotent
replacement of dead or damaged cells by the same type of cell as before; restores normal function
regeneration
replacement of damaged cells with scar tissue; does not restore function
fibrosis
shrinkage of a tissue through loss in cell size or number
atrophy
kind of atrophy ; occurs through normal aging
senile atrophy
kind of atrophy; from lack of use
disuse atrophy
pathological tissue death due to trauma, toxins, or infections
necrosis
sudden death of tissue when blood supply is cut off
infarction
tissue necrosis due to insufficient blood supply (usually with infection)
gangrene
bed sore; form of dry gangrene where continual pressure on skin of immobilized patient cuts off blood flow
decubitus ulcer
kind of gangrene: common complication of diabetes
dry gangrene
kind of gangrene; liquefaction of internal organs with infection
wet gangrene
kind of gangrene; usually from infection of soil bacterium that results in hydrogen bubbles in tissues
gas gangrene
programmed cell death
apoptosis
artificial production of tissues and organs in the lab for implantation in the human body
tissue engineering