Chapter 48 Questions Flashcards
Suppose a particular neurotransmitter causes an IPSP in postsynaptic cell X and an EPSP in postsynaptic cell Y. A likely explanation is that __________.
a. the threshold value in the postsynaptic membrane is different for cell X and cell Y
b. the axon of cell X is myelinated, but that of cell Y is not
c. only cell Y produces an enzyme that terminates the activity of the neurotransmitter
d. cells X and Y express different receptor molecules for this particular neurotransmitter
d. cells X and Y express different receptor molecules for this particular neurotransmitter
Gated ion channels
a. open and close in response to a stimulus.
b. are found only on vesicles.
c. require ATP hydrolysis.
d. move molecules against an electrochemical gradient.
a. open and close in response to a stimulus.
The sodium-potassium pump in the plasma membrane of cells
a. uses chemical energy to generate chemical gradients.
b. transports Na+ and K+ out of the cell.
c. converts ADP and Pi to ATP.
d. carries out a direct exchange of Na+ and K+.
a. uses chemical energy to generate chemical gradients.
In exocytosis, dissolved materials move from fluid
a. in the cytoplasm to fluid in the nucleus.
b. in the Golgi apparatus to fluid in the endoplasmic reticulum.
c. in vesicles to fluid outside of cells.
d. in lysosomes to the cytosol.
c. in vesicles to fluid outside of cells.
Choose the set that includes the most charged compounds that are more abundant inside neurons, in the cytosol, than outside the neurons, in the extracellular fluid.
a. potassium ions and proteins
b. chloride ions and proteins
c. proteins and sodium ions
d. sodium and chloride ions
e. sodium and potassium ions
a. potassium ions and proteins
Ions move in the direction opposite to that favored by the chemical concentration gradient when _____.
a. proteins leak out of a neuron
b. simple diffusion operates after active transport has been permanently halted by being poisoned
c. potassium ions exit the neuron during the repolarization phase of an action potential
d. sodium ions enter a neuron during the depolarization phase of an action potential
e. they are pumped by proteins that require ATP hydrolysis and when the electrical charge gradient repulses or attracts them
e. they are pumped by proteins that require ATP hydrolysis and when the electrical charge gradient repulses or attracts them
In a neuron, during the depolarization phase that may trigger an action potential _____.
a. some voltage-gated sodium channels are open
b. most voltage-gated sodium channels become inactivated
c. most voltage-gated sodium and potassium channels are open
d. most voltage-gated potassium channels are open
e. most voltage-gated sodium channels are open
a. some voltage-gated sodium channels are open
The simultaneous arrival of graded depolarization and a graded hyperpolarization of equal but opposite magnitude at a particular location on the dendritic membrane is likely to _____.
a. cause the apoptosis of the neuron
b. cancel each other out, making it appear as if there was no change in membrane potential
c. cause depolarization, because graded depolarizations are more important to neuron function
d. cause hyperpolarization, because graded hyperpolarizations are more important to neuron function
e. allow only the entry of sodium ions into the neuron, and prevent potassium ions from exiting the neuron
b. cancel each other out, making it appear as if there was no change in membrane potential
Select the choice that describes neurons with the fastest conduction velocity for action potentials.
a. thin, nonmyelinated neurons
b. thin, myelinated neurons
c. thick, myelinated neurons
d. thick, nonmyelinated neurons
e. All of these choices conduct action potentials at the same velocity.
c. thick, myelinated neurons
Of these choices, neuronal communication between the brain and the muscles of the leg is best conceptualized as _____.
a. the transcription of genes
b. electrical signaling
c. the transcription and translation of genes
d. chemical signaling
e. electrical and chemical signaling
e. electrical and chemical signaling
A nerve poison that blocks acetylcholine receptors on dendrites would _____.
a. inactivate acetylcholinesterase, allowing acetylcholine to persist in the synapse
b. cause continued stimulation of the postsynaptic membrane
c. reduce the binding of acetylcholine to its receptors on the postsynpatic membrane
d. inhibit the regeneration of acetylcholine for use by the presynaptic terminals
e. cause an immediate and enduring depolarization
c. reduce the binding of acetylcholine to its receptors on the postsynpatic membrane
At the neuromuscular junction, the arrival of acetylcholine on the muscle most immediately causes _____.
a. an inhibitory postsynaptic potential
b. a graded depolarization
c. the release of second messengers, such as cAMP
d. a single action potential
e. a graded hyperpolarization
b. a graded depolarization
Acetylcholine receptors on skeletal muscles are described as being “ionotropic” receptors because _____.
a. these receptors have a corequisite binding of magnesium ions in order to function
b. binding of acetylcholine to its receptor triggers release of a second messenger, e.g., cAMP, inside the muscle
c. binding of acetylcholine to the receptor protein converts the protein to an open ion channel
d. acetylcholine is an excitatory stimulus to the muscle
e. the receptors ionize as a result of binding acetylcholine, and this directly alters membrane potentials
c. binding of acetylcholine to the receptor protein converts the protein to an open ion channel
What happens when a resting neuron’s membrane depolarizes?
a. The equilibrium potential for K+ (E K) becomes more positive.
b. The neuron is less likely to generate an action potential.
c. The neuron’s membrane voltage becomes more positive.
d. There is a net diffusion of Na+ out of the cell.
e. The cell’s inside is more negative than the outside.
c. The neuron’s membrane voltage becomes more positive.
A common feature of action potentials is that they
a. require the diffusion of Na+ and K+ through ligand-gated channels to propagate.
b. move at the same speed along all axons.
c. are triggered by a depolarization that reaches the threshold.
d. cause the membrane to hyperpolarize and then depolarize.
e. can undergo temporal and spatial summation.
c. are triggered by a depolarization that reaches the threshold.
Where are neurotransmitter receptors located?
a. the postsynaptic membrane
b. the myelin sheath
c. synaptic vesicle membranes
d. the nuclear membrane
e. the nodes of Ranvier
a. the postsynaptic membrane
Why are action potentials usually conducted in one direction?
a. Voltage-gated channels for both Na+ and K+ open in only one direction.
b. Ions can flow along the axon in only one direction.
c. The nodes of Ranvier conduct potentials in one direction.
d. The axon hillock has a higher membrane potential than the terminals of the axon.
e. The brief refractory period prevents reopening of voltage-gated Na+ channels.
e. The brief refractory period prevents reopening of voltage-gated Na+ channels.
Which of the following is a direct result of depolarizing the presynaptic membrane of an axon terminal?
a. Synaptic vesicles fuse with the membrane.
b. Ligand-gated channels open, allowing neurotransmitters to enter the synaptic cleft.
c. An EPSP or IPSP is generated in the postsynaptic cell.
d. Voltage-gated calcium channels in the membrane open.
e. The postsynaptic cell produces an action potential.
d. Voltage-gated calcium channels in the membrane open.
Identify the correct statement(s) about the resting membrane potential of a cell.
Select all that apply.
a. Concentration gradients of potassium (K+) and sodium (Na+) across the plasma membrane represent potential energy.
b. Neurons are the only cells that have a charge difference across their membranes.
c. Potassium (K+) and sodium (Na+) gradients are maintained by active transport in a resting mammalian neuron.
a. Concentration gradients of potassium (K+) and sodium (Na+) across the plasma membrane represent potential energy.
c. Potassium (K+) and sodium (Na+) gradients are maintained by active transport in a resting mammalian neuron.
If the membrane potential of a neuron decreases, the membrane potential _____.
a. becomes more negative.
b. remains unchanged.
c. becomes less negative.
c. becomes less negative.
Why is an action potential an all-or-none response to stimuli?
a. Because voltage-gated ion channels open when membrane potential passes a particular level
b. Because a typical neuron receives signals through multiple dendrites but transmits signals through a single axon
c. Because neurons contain gated ion channels that are either open or closed
a. Because voltage-gated ion channels open when membrane potential passes a particular level
The plasma membrane of a neuron has voltage-gated sodium and potassium channels. What is the effect of membrane depolarization on these channels?
a. Membrane depolarization first opens sodium channels and then opens potassium channels.
b. Membrane depolarization opens sodium channels but closes potassium channels.
c. Membrane depolarization opens sodium and potassium channels at the same time.
a. Membrane depolarization first opens sodium channels and then opens potassium channels.
What causes the falling phase of the action potential? Select the best answer.
a. The opening of voltage-gated sodium channels
b. The opening of voltage-gated potassium channels
c. Inactivation of voltage-gated sodium channels and the opening of voltage-gated potassium channels
c. Inactivation of voltage-gated sodium channels and the opening of voltage-gated potassium channels
Which combination of axon features should lead an axon to communicate with downstream cells most slowly? An axon that is ____.
- long
- short
- wide
- thin
- myelinated
- nonmyelinated
a. 1, 3, and 5
b. 1, 3, and 6
c. 1, 4, and 6
d. 2, 3, and 5
e. 2, 4, and 6
c. 1, 4, and 6
In a typical motor neuron, what is the correct sequence in which these structures usually become involved in transmitting an electrical current? 1. cell body
- axon
- axon hillock
- dendrites
- synaptic terminals
a. 4, 1, 3, 2, 5
b. 5, 4, 1, 3, 2
c. 4, 3, 1, 2, 5
d. 5, 4, 1, 2, 3
e. 4, 1, 2, 3, 5
a. 4, 1, 3, 2, 5